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anti-GAB2 antibody :: Goat GAB2 Polyclonal Antibody

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Catalog # MBS420041
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

GAB2, Polyclonal Antibody

Also Known As

Goat anti-GAB2 Antibody

Product Synonym Names
GAB2; GRB2-associated binding protein 2; KIAA0571; Grb2-associated binder 2; GAB2 antibody; GRB2-associated binding protein 2 antibody; KIAA0571 antibody; Grb2-associated binder 2 antibody
Antibody/Peptide Pairs
GAB2 peptide (MBS425540) is used for blocking the activity of GAB2 antibody (MBS420041)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
676
Immunogen Sequence
QVDKEKTQAL QN
OMIM
606203
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-QVDKEKTQALQN, from the internal region (near the C Terminus) of the protein sequence according to NP_536739.1; NP_036428.1.
Epitope
Internal region (near the C Terminus)
Note
This antibody is expected to recognize both reported isoforms (NP_536739.1; NP_036428.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-GAB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GAB2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-GAB2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 80kDa band observed in lysates of cell line K562 (calculated MW of 74.5kDa according to NP_536739.1). Recommended concentration: 0.5-1.5ug/ml.

Western Blot (WB) of anti-GAB2 antibody
(0.5ug/ml) staining of K562 cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GAB2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for GAB2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_036428.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,968 Da
NCBI Official Full Name
GRB2-associated-binding protein 2 isoform a
NCBI Official Synonym Full Names
GRB2 associated binding protein 2
NCBI Official Symbol
NCBI Protein Information
GRB2-associated-binding protein 2
UniProt Protein Name
GRB2-associated-binding protein 2
UniProt Synonym Protein Names
GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100
UniProt Gene Name
UniProt Synonym Gene Names
KIAA0571  [Similar Products]
UniProt Entry Name
GAB2_HUMAN
NCBI Summary for GAB2
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
UniProt Comments for GAB2
GAB2: an adaptor protein of the GRB2-associated binding protein family. Plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11q14.1

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function: phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: osteoclast differentiation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of mast cell degranulation; transmembrane receptor protein tyrosine kinase signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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