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anti-NPY5R antibody :: Goat Neuropeptide Y receptor Y5 Polyclonal Antibody

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Catalog # MBS420766
Unit / Price
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  0.1 mg  /  $300 +1 FREE 8GB USB
Product Name

Neuropeptide Y receptor Y5 (NPY5R), Polyclonal Antibody

Full Product Name

Goat anti-Neuropeptide Y receptor Y5 Antibody

Product Synonym Names
neuropeptide Y receptor Y5; HGNC: 7958; NPY5R; NPYR5; neuropeptide Y receptor Y5 antibody; HGNC: 7958 antibody; NPY5R antibody; NPYR5 antibody; Neuropeptide Y receptor Y5; Neuropeptide Y receptor Y5
Matching Pairs
Unconjugated Antibody: Neuropeptide Y receptor Y5 (MBS420766)
Biotin Conjugated Antibody: Neuropeptide Y receptor Y5 (MBS423675)
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
GLSNKENRLE EN
OMIM
602001
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-GLSNKENRLEEN, from the internal region of the protein sequence according to NP_006165.1.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-NPY5R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NPY5R antibody
Peptide ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-NPY5R antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Intestine shows staining of ganglion cells. Recommended concentration, 4-6ug/ml.
Western Blot: Approx 50kDa band observed in Human Brain, Breast and Duodenum lysates (calculated MW of 50.7kDa according to NP_006165.1). Recommended concentration: 0.3-1ug/ml.
Immunoprecipitation: Customer feedback showed specific results when this product was used in IP.

Western Blot (WB) of anti-NPY5R antibody
(0.3ug/ml) staining of Human Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-NPY5R antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-NPY5R antibody
(3.8ug/ml) staining of paraffin embedded Human Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-NPY5R antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for NPY5R. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,727 Da
NCBI Official Full Name
neuropeptide Y receptor type 5
NCBI Official Synonym Full Names
neuropeptide Y receptor Y5
NCBI Official Symbol
NPY5R  [Similar Products]
NCBI Official Synonym Symbols
NPYR5; NPY5-R; NPYY5-R
  [Similar Products]
NCBI Protein Information
neuropeptide Y receptor type 5
UniProt Protein Name
Neuropeptide Y receptor type 5
UniProt Synonym Protein Names
NPY-Y5 receptor; NPYY5-R; Y5 receptor
Protein Family
UniProt Gene Name
NPY5R  [Similar Products]
UniProt Synonym Gene Names
NPYR5; NPY5-R; NPYY5-R; Y5 receptor  [Similar Products]
UniProt Entry Name
NPY5R_HUMAN
NCBI Summary for NPY5R
The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
UniProt Comments for NPY5R
NPY5R: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q31-q32

Cellular Component: cytoplasm; integral to plasma membrane; neuron projection; plasma membrane

Molecular Function: neuropeptide Y receptor activity; pancreatic polypeptide receptor activity; peptide YY receptor activity

Biological Process: cell surface receptor linked signal transduction; eating behavior; feeding behavior; G-protein coupled receptor protein signaling pathway; generation of ovulation cycle rhythm; negative regulation of apoptosis; negative regulation of glutamate secretion; negative regulation of synaptic transmission, GABAergic; neuropeptide signaling pathway; positive regulation of acute inflammatory response; positive regulation of smooth muscle cell proliferation; synaptic transmission
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-NPY5R antibody
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