• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-GRIN2B antibody :: Goat NMDAR2B/GRIN2B Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS420388
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

NMDAR2B/GRIN2B, Polyclonal Antibody

Popular Item
Also Known As

Goat anti-NMDAR2B/GRIN2B Antibody

Product Synonym Names
GRIN2B; NMDAR2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; HGNC: 4586; NR2B; hNR3; N-methyl-D-aspartate receptor subunit 2B; GRIN2B antibody; NMDAR2B antibody; glutamate receptor; ionotropic; N-methyl D-aspartate 2B antibody; HGNC: 4586 antibody; NR2B antibody; hNR3 antibody; N-methyl-D-aspartate receptor subunit 2B antibody; NMDAR2B / GRIN2B
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1484
Immunogen Sequence
KDAHEKDDFH HLS
OMIM
138252
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-KDAHEKDDFHHLS, from the internal region of the protein sequence according to NP_000825.1.
Epitope
Internal region
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1469
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-GRIN2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GRIN2B antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-GRIN2B antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 170kDa band observed in Rat Brain lysates (calculated MW of 166kDa according to NP_000825.1). Recommended concentration: 2-4ug/ml.

Western Blot (WB) of anti-GRIN2B antibody
(2ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GRIN2B antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for GRIN2B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
166,367 Da
NCBI Official Full Name
N-methyl-D-aspartate receptor subunit 2B
NCBI Official Synonym Full Names
glutamate ionotropic receptor NMDA type subunit 2B
NCBI Official Symbol
GRIN2B  [Similar Products]
NCBI Official Synonym Symbols
MRD6; NR2B; hNR3; EIEE27; GluN2B; NMDAR2B
  [Similar Products]
NCBI Protein Information
glutamate receptor ionotropic, NMDA 2B
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 2B
UniProt Synonym Protein Names
Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3
UniProt Gene Name
GRIN2B  [Similar Products]
UniProt Synonym Gene Names
NMDAR2B; GluN2B; NMDAR2B; NR2B; NR3; hNR3  [Similar Products]
UniProt Entry Name
NMDE2_HUMAN
NCBI Summary for GRIN2B
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]
UniProt Comments for GRIN2B
NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 12p12

Cellular Component: cell junction; cell surface; integral to plasma membrane; intracellular; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic membrane

Molecular Function: extracellular-glutamate-gated ion channel activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding

Biological Process: ephrin receptor signaling pathway; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; learning and/or memory; MAPKKK cascade; positive regulation of GTPase activity; response to ethanol; synaptic transmission; transport

Disease: Epileptic Encephalopathy, Early Infantile, 27; Mental Retardation, Autosomal Dominant 6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-GRIN2B antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >90 publications with GRIN2B and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000