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anti-SP140 antibody :: Rabbit SP140 Polyclonal Antibody

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Catalog # MBS835436
Unit / Price
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  0.1 mg  /  $390 +1 FREE 8GB USB
Product Name

SP140, Polyclonal Antibody

Popular Item
Full Product Name

SP140 antibody

Product Synonym Names
Polyclonal SP140; Anti-SP140; SP 140; SP-140; SP140 nuclear body protein; SP140
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
608602
3D Structure
ModBase 3D Structure for Q13342
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Dog
Form/Format
Lyophilized powder. Add 100 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration
1 mg/ml (lot specific)
Biological Significance
SP140 is the nuclear body protein found specifically in all NP cells. HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif.
Immunogen
SP140 antibody was raised in rabbit using the N terminal of SP140 as the immunogen
Preparation and Storage
Store at 4 degree C, following reconstitution, aliquot and store at -20 degree C. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-SP140 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SP140 antibody
Rabbit polyclonal SP140 antibody
Product Categories/Family for anti-SP140 antibody
Applications Tested/Suitable for anti-SP140 antibody
Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-SP140 antibody
Optimal conditions to be determined by the end user

Western Blot (WB) of anti-SP140 antibody
Western Blot showing SP140 antibody used at a concentration of 5.0 ug/ml against Raji Cell Lysate
anti-SP140 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-SP140 antibody
SP140 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Epithelial cells of renal tubule (arrows) in Human Kidney. Magnification is at 400X
anti-SP140 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for SP140. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91,673 Da
NCBI Official Full Name
nuclear body protein SP140 isoform 2
NCBI Official Synonym Full Names
SP140 nuclear body protein
NCBI Official Symbol
SP140  [Similar Products]
NCBI Official Synonym Symbols
LYSP100; LYSP100-A; LYSP100-B
  [Similar Products]
NCBI Protein Information
nuclear body protein SP140
UniProt Protein Name
Nuclear body protein SP140
UniProt Synonym Protein Names
Lymphoid-restricted homolog of Sp100
Protein Family
UniProt Gene Name
SP140  [Similar Products]
UniProt Synonym Gene Names
LYSp100  [Similar Products]
UniProt Entry Name
SP140_HUMAN
UniProt Comments for SP140
SP140: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: nucleoplasm; PML body; cytoplasm; nuclear envelope; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; chromatin binding; transcription factor activity

Biological Process: chromatin remodeling; regulation of transcription, DNA-dependent; defense response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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