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anti-HNF1A antibody :: Goat TCF1/HNF1 Polyclonal Antibody

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Catalog # MBS420686
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-HNF1A antibody
Product Name

TCF1/HNF1 (HNF1A), Polyclonal Antibody

Popular Item
Full Product Name

Goat anti-TCF1/HNF1 Antibody

Product Synonym Names
Goat Anti-HNF1A Antibody; TCF1; transcription factor 1, hepatic LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor; HNF1; HNF1A; LFB1; MODY3; Interferon production regulator factor (HNF1); albumin proximal factor; hepatic nuclear factor 1; maturity onset diabetes of t; TCF1 antibody; transcription factor 1; hepatic LF-B1; hepatic nuclear factor (HNF1); albumin proximal factor antibody; HNF1 antibody; HNF1A antibody; LFB1 antibody; MODY3 antibody; Interferon production regulator factor (HNF1) antibody; albumin proximal factor antibody; hepatic nuclear factor 1 antibody; maturity onset diabetes of the young 3 antibody; transcription factor 1; hepatic antibody; TCF1 / HNF1
Product Synonym Gene Name
TCF1; HNF1[Similar Products]
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
DELPTKKGRR NRFK
OMIM
142330
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-DELPTKKGRRNRFK, from the internal region of the protein sequence according to NP_000536.3.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-HNF1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HNF1A antibody
Peptide ELISA (EIA)
Application Notes for anti-HNF1A antibody
Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments in human liver and kidney lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
NCBI/Uniprot data below describe general gene information for HNF1A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,491 Da
NCBI Official Full Name
transcription factor 1, hepatic
NCBI Official Synonym Full Names
HNF1 homeobox A
NCBI Official Symbol
HNF1A  [Similar Products]
NCBI Official Synonym Symbols
HNF1; LFB1; TCF1; MODY3; TCF-1; HNF-1A; IDDM20
  [Similar Products]
NCBI Protein Information
hepatocyte nuclear factor 1-alpha
UniProt Protein Name
Hepatocyte nuclear factor 1-alpha
UniProt Synonym Protein Names
Liver-specific transcription factor LF-B1; LFB1; Transcription factor 1; TCF-1
Protein Family
UniProt Gene Name
HNF1A  [Similar Products]
UniProt Synonym Gene Names
TCF1; HNF-1-alpha; HNF-1A; LFB1; TCF-1  [Similar Products]
UniProt Entry Name
HNF1A_HUMAN
NCBI Summary for HNF1A
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
UniProt Comments for HNF1A
HNF1A: Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. Defects in HNF1A are a cause of hepatic adenomas familial (HEPAF). Hepatic adenomas are rare benign liver tumors of presumable epithelial origin that develop in an otherwise normal liver. Hepatic adenomas may be single or multiple. They consist of sheets of well-differentiated hepatocytes that contain fat and glycogen and can produce bile. Bile ducts or portal areas are absent. Kupffer cells, if present, are reduced in number and are non-functional. Conditions associated with adenomas are insulin-dependent diabetes mellitus and glycogen storage diseases (types 1 and 3). Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas. Defects in HNF1A are the cause of maturity-onset diabetes of the young type 3 (MODY3); also symbolized MODY-3. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Defects in HNF1A are the cause of susceptibility to diabetes mellitus insulin-dependent type 20 (IDDM20). IDDM20 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These features can result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Belongs to the HNF1 homeobox family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: cytoplasm; nucleus; protein complex

Molecular Function: DNA binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; transcription factor activity

Biological Process: glucose homeostasis; glucose import; insulin secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter

Disease: Diabetes Mellitus, Insulin-dependent; Diabetes Mellitus, Insulin-dependent, 20; Diabetes Mellitus, Noninsulin-dependent; Hepatic Adenomas, Familial; Maturity-onset Diabetes Of The Young, Type 3; Renal Cell Carcinoma, Nonpapillary
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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