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anti-WAS antibody :: Goat Wiskott-Aldrich Syndrome/WASP Polyclonal Antibody

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Catalog # MBS420239
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Wiskott-Aldrich Syndrome/WASP, Polyclonal Antibody

Full Product Name

Goat anti-Wiskott-Aldrich Syndrome/WASP Antibody

Product Synonym Names
WAS; WASP; Wiskott-Aldrich syndrome (eczema-thrombocytopenia); THC; IMD2; thrombocytopenia 1 (X-linked); Wiskott-Aldrich syndrome (eczema-thrombocytopenia) protein; THC1; Wiskott-Aldrich syndrome protein; WASP antibody; Wiskott-Aldrich syndrome (eczema-thrombocytopenia) antibody; WAS antibody; THC antibody; IMD2 antibody; thrombocytopenia 1 (X-linked) antibody; Wiskott-Aldrich syndrome (eczema-thrombocytopenia) protein antibody; THC1 antibody; Wiskott-Aldrich syndrome protein antibody; Wiskott-Aldrich Syndrome; Wiskott-Aldrich Syndrome / WASP
Product Gene Name
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
100ug specific antibody in 200ul (lot specific)
Peptide with sequence C-SPADKKRSGKKKI, from the internal region of the protein sequence according to NP_000368.1.
Internal region
No cross-reactivity expected with N WASP (WASL).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-WAS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-WAS antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-WAS antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 60kDa band observed in Human lysates of Tcell line MOLT4 and monocytic cell line U937 (calculated MW of 52.9kDa according to NP_000368.1). Recommended concentration: 0. 03-0.1ug/ml.

Western Blot (WB) of anti-WAS antibody
Staining (0. 03ug/ml) of U937 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-WAS antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for WAS. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,913 Da
NCBI Official Full Name
wiskott-Aldrich syndrome protein
NCBI Official Synonym Full Names
Wiskott-Aldrich syndrome
NCBI Official Symbol
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
wiskott-Aldrich syndrome protein
UniProt Protein Name
Wiskott-Aldrich syndrome protein
UniProt Gene Name
UniProt Synonym Gene Names
IMD2; WASp  [Similar Products]
UniProt Entry Name
NCBI Summary for WAS
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq, Jul 2008]
UniProt Comments for WAS
WASP: a member of the Wiskott-Aldrich syndrome (WAS) family of proteins. A cytoplasmic protein expressed exclusively in hematopoietic cells. Transduces signals from surface receptors to the actin cytoskeleton. Associates with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Mutated in Wiskott-Aldrich syndrome, a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xp11.4-p11.21

Cellular Component: actin cytoskeleton; cytosol; intercellular junction; vesicle membrane

Molecular Function: actin binding; GTPase regulator activity; identical protein binding; phospholipase binding; protein binding; protein kinase binding; SH3 domain binding

Biological Process: actin filament polymerization; actin filament-based movement; actin polymerization and/or depolymerization; blood coagulation; defense response; endosome transport; epidermis development; immune response; protein complex assembly; regulation of catalytic activity; regulation of T cell antigen processing and presentation; T cell activation; T cell receptor signaling pathway

Disease: Neutropenia, Severe Congenital, X-linked; Thrombocytopenia 1
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