NP_033183.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
dual specificity mitogen-activated protein kinase kinase 4
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase 4
NCBI Official Synonym Symbols
MEK4; MKK4; Sek1; JNKK1; Serk1; PRKMK4 [Similar Products]
NCBI Protein Information
dual specificity mitogen-activated protein kinase kinase 4
UniProt Protein Name
Dual specificity mitogen-activated protein kinase kinase 4
UniProt Synonym Protein Names
C-JUN N-terminal kinase kinase 1; JNK kinase 1; JNKK 1; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1
UniProt Synonym Gene Names
Jnkk1; Mek4; Mkk4; Prkmk4; Sek1; Serk1; Skk1; MAP kinase kinase 4; MAPKK 4; JNK kinase 1; JNKK 1; MEK 4; SEK1 [Similar Products]
UniProt Entry Name
MP2K4_MOUSE
UniProt Comments for Map2k4
MKK4: dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38 but not ERK1 or -2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction.
Protein type: Protein kinase, dual-specificity (non-receptor); Protein kinase, STE; Kinase, protein; EC 2.7.12.2; STE group; STE7 family
Cellular Component: dendrite cytoplasm; axon; cytoplasm; perikaryon; intracellular; nucleus; cytosol
Molecular Function: MAP kinase kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; mitogen-activated protein kinase kinase kinase binding; JUN kinase kinase activity; ATP binding; protein kinase activity
Biological Process: positive regulation of apoptosis; apoptosis; positive regulation of neuron apoptosis; MAPKKK cascade; JNK cascade; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; phosphorylation; positive regulation of DNA replication; activation of JNK activity; positive regulation of nitric-oxide synthase biosynthetic process
Product References and Citations for anti-Map2k4 antibody
Finegan, K.G., et al. Cancer Res. 70(14):5797-5806(2010) Ahn, Y.H., et al. J. Biol. Chem. 284(43):29399-29404(2009) Bogani, D., et al. PLoS Biol. 7 (9), E1000196 (2009) : Liu, W., et al. Circ. Res. 104(7):905-914(2009) Bulat, N., et al. J. Lipid Res. 50(1):81-89(2009)
Research Articles on Map2k4
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Products associated with anti-Map2k4 antibody
Pathways associated with anti-Map2k4 antibody
Diseases associated with anti-Map2k4 antibody
Organs/Tissues associated with anti-Map2k4 antibody
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