NP_443082.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,384 Da
NCBI Official Full Name
growth arrest and DNA damage-inducible proteins-interacting protein 1
NCBI Official Synonym Full Names
growth arrest and DNA-damage-inducible, gamma interacting protein 1
NCBI Official Synonym Symbols
PRG6; CRIF1; PLINP; CKBBP2; Plinp1; MRP-L59; PLINP-1; CKbetaBP2 [Similar Products]
NCBI Protein Information
growth arrest and DNA damage-inducible proteins-interacting protein 1
UniProt Protein Name
Growth arrest and DNA damage-inducible proteins-interacting protein 1
UniProt Synonym Protein Names
39S ribosomal protein L59, mitochondrial; MRP-L59; CKII beta-associating protein; CR6-interacting factor 1; CRIF1; Papillomavirus L2-interacting nuclear protein 1; PLINP; PLINP-1; p53-responsive gene 6 protein
UniProt Synonym Gene Names
UniProt Entry Name
G45IP_HUMAN
NCBI Summary for GADD45GIP1
This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
UniProt Comments for GADD45GIP1
GADD45GIP1: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Down-regulated by p53/TP53 in apoptotic cells. Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: mitochondrion; mitochondrial matrix; nucleus
Molecular Function: protein binding
Biological Process: viral reproduction; mitochondrial translation; organelle organization and biogenesis; cell cycle
Research Articles on GADD45GIP1
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Products associated with anti-GADD45GIP1 antibody
Pathways associated with anti-GADD45GIP1 antibody
Diseases associated with anti-GADD45GIP1 antibody
Organs/Tissues associated with anti-GADD45GIP1 antibody
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