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anti-VR1 antibody :: Rabbit VR1 / TRPV1 Polyclonal Antibody

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Catalog # MBS244558
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

VR1 / TRPV1, Polyclonal Antibody

Also Known As

Rabbit Polyclonal to Human VR1 / TRPV1

Product Synonym Names
Anti-VR1 / TRPV1 Antibody (Internal) IHC-plus; TRPV1; Capsaicin receptor; OTRPC1; Vanilloid receptor subtype 1; Osm-9-like TRP channel 1; Vanilloid receptor 1; VR1; Human VR1; TRPV1
Product Gene Name
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
839
OMIM
602076
3D Structure
ModBase 3D Structure for Q8NER1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Guinea pig, Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
Specificity
Human TRPV1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from internal region of human TRPV1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Guinea pig (100%); Monkey (94%); Horse (82%).
Immunogen Type
Synthetic peptide
Immunogen
VR1 / TRPV1 antibody was raised against synthetic 17 amino acid peptide from internal region of human TRPV1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Guinea pig (100%); Monkey (94%); Horse (82%).
Antigen Modification
Internal
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-VR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-VR1 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-VR1 antibody
IHC-P (5 ug/ml)

Immunohistochemistry (IHC) of anti-VR1 antibody
Anti-TRPV1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-VR1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for VR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
94,211 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily V member 1
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily V, member 1
NCBI Official Symbol
TRPV1  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
transient receptor potential cation channel subfamily V member 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; vanilloid receptor subtype 1; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b
UniProt Protein Name
Transient receptor potential cation channel subfamily V member 1
UniProt Synonym Protein Names
Capsaicin receptor; Osm-9-like TRP channel 1; OTRPC1; Vanilloid receptor 1
UniProt Gene Name
TRPV1  [Similar Products]
UniProt Synonym Gene Names
VR1; TrpV1; OTRPC1  [Similar Products]
UniProt Entry Name
TRPV1_HUMAN
NCBI Summary for VR1
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for VR1
TRPV1: a receptor for capsaicin and a non-selective cation channel that is structurally related to members of the TRP family of ion channels. Activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.; Channel, cation

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: postsynaptic membrane; integral to plasma membrane; integral to membrane; plasma membrane; cell junction; intrinsic to plasma membrane

Molecular Function: calmodulin binding; transmembrane receptor activity; excitatory extracellular ligand-gated ion channel activity; calcium-release channel activity; calcium channel activity; phosphoprotein binding; ATP binding

Biological Process: cell surface receptor linked signal transduction; transport; chemosensory behavior; thermoception; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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