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anti-CYSLT2 antibody :: Rabbit CYSLT2 / CYSLTR2 Polyclonal Antibody

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Catalog # MBS240917
Unit / Price
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  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

CYSLT2 / CYSLTR2, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human CYSLT2 / CYSLTR2

Product Synonym Names
Anti-CYSLT2 / CYSLTR2 Antibody (Extracellular Domain) IHC-plus; CYSLTR2; CysLT(2); CYSLT2; CYSLT2R; CysLT-2; HG57; HGPCR21; KPG_011; PSEC0146; HPN321; Human CYSLT2; CYSLTR2
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605666
3D Structure
ModBase 3D Structure for Q9NS75
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Horse, Human
Predicted Reactivity: Gorilla, Monkey, Mouse (at least 90% immunogen sequence identity)
Specificity
Human CYSLTR2 / CYSLT2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GPR109B (59%), OXGR1 (59%), GPR81 (59%).
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from 1st extracellular domain of human CYSLTR2 / CYSLT2. Percent identity with other species by BLAST analysis: Human, Gibbon, Marmoset, Horse (100%); Gorilla, Monkey, Mouse, Panda (94%)
Immunogen Type
Synthetic peptide
Immunogen
CYSLT2 / CYSLTR2 antibody was raised against synthetic 17 amino acid peptide from 1st extracellular domain of human CYSLTR2 / CYSLT2. Percent identity with other species by BLAST analysis: Human, Gibbon, Marmoset, Horse (100%); Gorilla, Monkey, Mouse, Panda (94%); Dog, Bovine, Hamster, Elephant, Rabbit, Opossum (88%); Pig (82%).
Antigen Modification
Extracellular Domain
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-CYSLT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CYSLT2 antibody
Cysteinyl leukotriene receptor 2 (CysLT2) is a Chemoattractant Receptor that binds neutrophil chemoattractants such as cysteinyl leukotrienes. These ligands have potent proinflammatory activity and are implicated in many features of asthma including edema, bronchial constriction, and hyperreactivity (Bisgaard et al., 2000). Activation of cysteinyl leukotriene receptor 2 induces cell contraction and/or relaxation.
Applications Tested/Suitable for anti-CYSLT2 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-CYSLT2 antibody
ELISA, IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-CYSLT2 antibody
Anti-CYSLTR2 / CYSLT2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-CYSLT2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for CYSLT2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,635 Da
NCBI Official Full Name
cysteinyl leukotriene receptor 2
NCBI Official Synonym Full Names
cysteinyl leukotriene receptor 2
NCBI Official Symbol
CYSLTR2  [Similar Products]
NCBI Official Synonym Symbols
HG57; CYSLT2; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146
  [Similar Products]
NCBI Protein Information
cysteinyl leukotriene receptor 2; G protein-coupled receptor; G-protein coupled receptor HG57; G-protein coupled receptor GPCR21; cysteinyl leukotriene CysLT2 receptor
UniProt Protein Name
Cysteinyl leukotriene receptor 2
UniProt Synonym Protein Names
G-protein coupled receptor GPCR21; hGPCR21; G-protein coupled receptor HG57; HPN321
UniProt Gene Name
CYSLTR2  [Similar Products]
UniProt Synonym Gene Names
CYSLT2; CYSLT2R; CysLTR2; hGPCR21  [Similar Products]
UniProt Entry Name
CLTR2_HUMAN
NCBI Summary for CYSLT2
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
UniProt Comments for CYSLT2
CYSLTR2: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 13q14.2

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; cysteinyl leukotriene receptor activity; leukotriene receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; immune response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-CYSLT2 antibody
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >1 publications with CYSLT2 and Placenta
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