NP_060955.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,080 Da
NCBI Official Full Name
C5a anaphylatoxin chemotactic receptor 2
NCBI Official Synonym Full Names
complement component 5a receptor 2
NCBI Protein Information
C5a anaphylatoxin chemotactic receptor 2; G protein-coupled receptor 77; G protein-coupled receptor C5L2; C5a anaphylatoxin chemotactic receptor C5L2
UniProt Protein Name
C5a anaphylatoxin chemotactic receptor 2
UniProt Synonym Protein Names
Complement component 5a receptor 2; G-protein coupled receptor 77
UniProt Synonym Gene Names
UniProt Entry Name
C5AR2_HUMAN
NCBI Summary for C5AR2
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
UniProt Comments for C5AR2
C5AR2: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: apical part of cell; integral to membrane; basal plasma membrane; plasma membrane
Molecular Function: protein binding; C5a anaphylatoxin receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of tumor necrosis factor production; inflammatory response; chemotaxis; positive regulation of epithelial cell proliferation
Research Articles on C5AR2
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Products associated with anti-C5AR2 antibody
Pathways associated with anti-C5AR2 antibody
Diseases associated with anti-C5AR2 antibody
Organs/Tissues associated with anti-C5AR2 antibody
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