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anti-KATII antibody :: Rabbit KATII / AADAT Polyclonal Antibody

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Catalog # MBS241510
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

KATII / AADAT, Polyclonal Antibody

Also Known As

Rabbit Polyclonal to Human KATII / AADAT

Product Synonym Names
Anti-KATII / AADAT Antibody (Internal) IHC-plus; AADAT; 2-aminoadipate transaminase; KAT2; KAT; AadAT; KATII; Kynurenine aminotransferase II; Aminoadipate aminotransferase; Human KATII; AADAT
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
425
OMIM
611754
3D Structure
ModBase 3D Structure for Q8N5Z0
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human, Monkey
Specificity
Human AADAT. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TARSL2 (47%).
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from internal region of human AADAT. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Monkey (88%); Dog, Elephant (82%).
Immunogen Type
Synthetic peptide
Immunogen
KATII / AADAT antibody was raised against synthetic 17 amino acid peptide from internal region of human AADAT. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset (100%); Monkey (88%); Dog, Elephant (82%).
Antigen Modification
Internal
Preparation and Storage
Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
Other Notes
Small volumes of anti-KATII antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KATII antibody
Kynurenine aminotransferase catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid. Kynurenic acid is an antagonist at the glycine site of NMDA receptors and increased levels of kynurenic acid are thought to exert a neuroprotective action in some pathological conditions.
Applications Tested/Suitable for anti-KATII antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-KATII antibody
IHC-P (5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-KATII antibody
Anti-AADAT antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-KATII antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for KATII. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,822 Da
NCBI Official Full Name
kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform b
NCBI Official Synonym Full Names
aminoadipate aminotransferase
NCBI Official Symbol
AADAT  [Similar Products]
NCBI Official Synonym Symbols
KAT2; KATII
  [Similar Products]
NCBI Protein Information
kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; KAT/AadAT; 2-aminoadipate transaminase; kynurenine aminotransferase II; 2-aminoadipate aminotransferase; kynurenine--oxoglutarate transaminase 2; kynurenine--oxoglutarate transaminase II; kynurenine--oxoglutarate aminotransferase II; L kynurenine/alpha aminoadipate aminotransferase
UniProt Protein Name
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
UniProt Synonym Protein Names
2-aminoadipate aminotransferase; 2-aminoadipate transaminase (EC:2.6.1.39); Alpha-aminoadipate aminotransferase; AadAT; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2 (EC:2.6.1.7); Kynurenine--oxoglutarate transaminase II
UniProt Gene Name
AADAT  [Similar Products]
UniProt Synonym Gene Names
KAT2; KAT/AadAT; AadAT  [Similar Products]
UniProt Entry Name
AADAT_HUMAN
NCBI Summary for KATII
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
UniProt Comments for KATII
AADAT: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - lysine biosynthesis; Amino Acid Metabolism - tryptophan; EC 2.6.1.7; EC 2.6.1.39; Transferase; Mitochondrial

Chromosomal Location of Human Ortholog: 4q33

Cellular Component: mitochondrial matrix

Molecular Function: protein homodimerization activity; kynurenine-oxoglutarate transaminase activity; 2-aminoadipate transaminase activity; pyridoxal phosphate binding

Biological Process: glutamate metabolic process; tryptophan catabolic process to kynurenine; L-lysine catabolic process to acetyl-CoA via saccharopine; lysine catabolic process; biosynthetic process; tryptophan catabolic process; 2-oxoglutarate metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Products associated withanti-KATII antibody
Organs/Tissues associated with anti-KATII antibody
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