• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-ADRA1B antibody :: Rabbit ADRA1B Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS240877
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

ADRA1B, Polyclonal Antibody

Also Known As

Rabbit Polyclonal to Human ADRA1B

Product Synonym Names
Anti-ADRA1B Antibody (C-Terminus) IHC-plus; ADRA1B; Alpha 1b; Alpha-1B adrenergic receptor; Alpha-1b-adrenergic; Alpha-1B-adrenergic receptor; Alpha1b; Adrenoceptor alpha 1B; Alpha-1B adrenoreceptor; Alpha1B-AR; Alpha1beta-AR; ALPHA1BAR; ADRA1; Alpha-1B adrenoceptor; Alpha1b-adrenergic; Human ADRA1B
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
520
OMIM
104220
3D Structure
ModBase 3D Structure for P35368
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
Specificity
Human ADRA1B. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human ADRA1B. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (95%); Mouse, Hamster, Elephant (85%).
Immunogen Type
Synthetic peptide
Immunogen
ADRA1B antibody was raised against synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human ADRA1B. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (95%); Mouse, Hamster, Elephant (85%).
Antigen Modification
C-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-ADRA1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADRA1B antibody
The alpha-1b adrenoceptor is an Adrenergic Receptor that causes contraction of smooth muscle cells and thereby controls vascular tone, blood pressure, and accelerates the development of atherosclerosis. Decreased alpha-1b adrenoceptor is associated with benign prostatic hyperplasia (BPH). This adrenergic receptor also acts as a proto-oncogene when transfected into cell lines where constitutive activation of the receptor induces neoplastic transformation.
Applications Tested/Suitable for anti-ADRA1B antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-ADRA1B antibody
ELISA, IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-ADRA1B antibody
Anti-ADRA1B antibody IHC of human smooth muscle cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ADRA1B antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ADRA1B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,836 Da
NCBI Official Full Name
alpha-1B adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 1B
NCBI Official Symbol
ADRA1B  [Similar Products]
NCBI Official Synonym Symbols
ADRA1; ALPHA1BAR
  [Similar Products]
NCBI Protein Information
alpha-1B adrenergic receptor; alpha-1B adrenoceptor; alpha-1B adrenoreceptor; alpha-1B-adrenergic receptor; adrenergic, alpha-1B-, receptor
UniProt Protein Name
Alpha-1B adrenergic receptor
UniProt Synonym Protein Names
Alpha-1B adrenoreceptor; Alpha-1B adrenoceptor
UniProt Gene Name
ADRA1B  [Similar Products]
UniProt Synonym Gene Names
Alpha-1B adrenoceptor  [Similar Products]
UniProt Entry Name
ADA1B_HUMAN
NCBI Summary for ADRA1B
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
UniProt Comments for ADRA1B
ADRA1B: a G protein-coupled catecholamine receptor that activates mitogenic responses and regulates growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. Can induce neoplastic transformation when transfected into cell lines. Can regulate the phosphorylation status of the STAT3 pathway. Mediates blood pressure and aorta contractile responses induced by alpha-1 agonists. Activates a phosphatidylinositol second messenger system.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: nuclear membrane; integral to plasma membrane; plasma membrane; nucleus

Molecular Function: protein heterodimerization activity; alpha1-adrenergic receptor activity

Biological Process: adult heart development; vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure; positive regulation of the force of heart contraction by epinephrine-norepinephrine; multicellular organismal development; response to amphetamine; response to morphine; locomotory behavior; glucose homeostasis; positive regulation of glycogen catabolic process; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; cell proliferation; organ growth; cell-cell signaling; positive regulation of MAPKKK cascade; behavioral response to cocaine; regulation of vasoconstriction; visual learning; blood vessel remodeling; cell growth; positive regulation of heart rate by epinephrine-norepinephrine; negative regulation of glycogen catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000