NP_004404.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,674 Da
NCBI Official Full Name
dipeptidase 1
NCBI Official Synonym Full Names
dipeptidase 1 (renal)
NCBI Protein Information
dipeptidase 1; hRDP; renal dipeptidase; dehydropeptidase-I; microsomal dipeptidase
UniProt Protein Name
Dipeptidase 1
UniProt Synonym Protein Names
Dehydropeptidase-I; Microsomal dipeptidase; Renal dipeptidase; hRDP
UniProt Synonym Gene Names
UniProt Entry Name
DPEP1_HUMAN
NCBI Summary for DPEP1
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for DPEP1
DPEP1: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. Belongs to the peptidase M19 family.
Protein type: Membrane protein, GPI anchor; EC 3.4.13.19; Protease
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component: extracellular space; microvillus membrane; apical part of cell; apical plasma membrane; plasma membrane; cell junction; nucleus
Molecular Function: protein binding; metalloexopeptidase activity; zinc ion binding; dipeptidyl-peptidase activity; caspase inhibitor activity
Biological Process: glutathione metabolic process; xenobiotic metabolic process; arachidonic acid metabolic process; leukotriene metabolic process; negative regulation of caspase activity; homocysteine metabolic process; proteolysis; negative regulation of cell migration; antibiotic metabolic process; negative regulation of apoptosis
Research Articles on DPEP1
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Pathways associated with anti-DPEP1 antibody
Diseases associated with anti-DPEP1 antibody
Organs/Tissues associated with anti-DPEP1 antibody
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