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anti-ITGA3 antibody :: Rabbit ITGA3 / CD49c Polyclonal Antibody

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Catalog # MBS243261
Unit / Price
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  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

ITGA3 / CD49c, Polyclonal Antibody

Popular Item
Full Product Name

Rabbit Polyclonal to Human ITGA3 / CD49c

Product Synonym Names
Anti-ITGA3 / CD49c Antibody (Internal) IHC-plus; ITGA3; Alpha3 integrin; CD49c antigen; CD49C; GAPB3; Integrin alpha-3; FRP-2; VCA-2; VLA-3 subunit alpha; VL3A; VLA3a; Galactoprotein B3; GAP-B3; ILNEB; Integrin alpha3; MSK18; Human ITGA3; CD49c
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 614748
3D Structure
ModBase 3D Structure for P26006
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Reactivity: Human, Monkey
Predicted Reactivity: Guinea pig, Hamster, Rabbit
Specificity
Human ITGA3 / CD49c. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, less than 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Target
ITGA3/CD49c
Target Species
Human
Family/Subfamily
Integrin/not assigned-Integrin
Immunogen Sppecies
ITGA3/CD49c antibody was raised against Human
Epitope
Internal
Immunogen Type
Synthetic peptide
Immunogen
ITGA3 / CD49c antibody was raised against synthetic 18 amino acid peptide from internal region of human ITGA3 / CD49c. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey (100%); Gibbon, Galago, Hamster, Elephant, Rabbit, Guinea pig (94%); Marmoset, Mouse, Rat, Panda, Bovine, Bat, Horse (89%); Pig (83%).
Antigen Modification
Internal
Preparation and Storage
Upon arrival: Aliquot and store undiluted at -20 degree C or below for up to 1 yr. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze thaw cycles.
Other Notes
Small volumes of anti-ITGA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ITGA3 antibody
ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 (‘VLA-3). Very common antigen 2 (‘VCA-2’), extracellular matrix receptor 1 (‘ECMR1’), and galactoprotein b3 (‘GAPB3’).
Product Categories/Family for anti-ITGA3 antibody
Applications Tested/Suitable for anti-ITGA3 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-ITGA3 antibody
IHC-P (2.5 - 5 ug/ml)

Immunohistochemistry (IHC) of anti-ITGA3 antibody
Anti-ITGA3 / CD49c antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ITGA3 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ITGA3 antibody
Anti-ITGA3 / CD49c antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ITGA3 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ITGA3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
118,756 Da
NCBI Official Full Name
integrin alpha-3 isoform a
NCBI Official Synonym Full Names
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
NCBI Official Symbol
ITGA3  [Similar Products]
NCBI Official Synonym Symbols
VL3A; CD49C; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3
  [Similar Products]
NCBI Protein Information
integrin alpha-3; FRP-2; galactoprotein B3; VLA-3 subunit alpha; CD49 antigen-like family member C; antigen identified by monoclonal antibody J143; very late activation protein 3 receptor, alpha-3 subunit
UniProt Protein Name
Integrin alpha-3
UniProt Synonym Protein Names
CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD_antigen: CD49cCleaved into the following 2 chains:Integrin alpha-3 heavy chain; Integrin alpha-3 light chain
Protein Family
UniProt Gene Name
ITGA3  [Similar Products]
UniProt Synonym Gene Names
MSK18; GAPB3  [Similar Products]
UniProt Entry Name
ITA3_HUMAN
NCBI Summary for ITGA3
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for ITGA3
ITGA3: an integral membrane protein that heterodimerizes with a beta chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. Undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1. Two alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: filopodium membrane; growth cone; focal adhesion; cell surface; perinuclear region of cytoplasm; basolateral plasma membrane; plasma membrane; excitatory synapse; integrin complex; receptor complex; external side of plasma membrane

Molecular Function: integrin binding; collagen binding; protein domain specific binding; protein binding; protease binding; protein heterodimerization activity; fibronectin binding; metal ion binding; laminin binding; glycoprotein binding

Biological Process: skin development; response to drug; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; maternal process involved in pregnancy; cell-matrix adhesion; heart development; regulation of BMP signaling pathway; neuron migration; regulation of Wnt receptor signaling pathway; mesodermal cell differentiation; memory; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of Rho protein signal transduction; blood coagulation; leukocyte migration; negative regulation of cell projection organization and biogenesis; lung development

Disease: Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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