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anti-PREPL antibody :: Rabbit PREPL Polyclonal Antibody

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Catalog # MBS9205980
Unit / Price
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  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Product Name

PREPL, Polyclonal Antibody

Full Product Name

PREPL Antibody (C-term)

Product Synonym Names
Prolyl endopeptidase-like; 3421-; Prolylendopeptidase-like; PREPL; KIAA0436
Antibody/Peptide Pairs
PREPL peptide (MBS9225695) is used for blocking the activity of PREPL antibody (MBS9205980)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
624-652
OMIM
606407
3D Structure
ModBase 3D Structure for Q4J6C6
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, hamster, mouse (Predicted Reactivity: Monkey, Rat)
Specificity
This PREPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-652 amino acids from the C-terminal region of human PREPL.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-PREPL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PREPL antibody
The protein encoded by this gene belongs to the prolyl
oligopeptidase subfamily of serine peptidases. Mutations in this
gene have been associated with hypotonia-cystinuria syndrome, also
known as the 2p21 deletion syndrome.
Product Categories/Family for anti-PREPL antibody
Applications Tested/Suitable for anti-PREPL antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-PREPL antibody
WB~~1:1000

Western Blot (WB) of anti-PREPL antibody
PREPL Antibody (C-term) western blot analysis in CHO cell line lysates (15ug/lane).This demonstrates the PREPL antibody detected the PREPL protein (arrow).
anti-PREPL antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-PREPL antibody
PREPL Antibody (C-term) western blot analysis in mouse stomach tissue lysates (15ug/lane).This demonstrates the PREPL antibody detected the PREPL protein (arrow).
anti-PREPL antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PREPL antibody
PREPL Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PREPL Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-PREPL antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PREPL. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Human, hamster, mouse (Predicted Reactivity: Monkey, Rat)NP_001035845.1; NP_001165074.1; NP_001165077.1; NP_001165084.1; NP_001165088.1; NP_006027.2[Other Products]
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83927
NCBI Official Full Name
prolyl endopeptidase-like isoform 2
NCBI Official Synonym Full Names
prolyl endopeptidase-like
NCBI Official Symbol
PREPL  [Similar Products]
NCBI Protein Information
prolyl endopeptidase-like
UniProt Protein Name
Prolyl endopeptidase-like
UniProt Synonym Protein Names
Prolylendopeptidase-like
Protein Family
UniProt Gene Name
PREPL  [Similar Products]
UniProt Synonym Gene Names
KIAA0436  [Similar Products]
UniProt Entry Name
PPCEL_HUMAN
NCBI Summary for PREPL
The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.[provided by RefSeq, Jan 2010]
UniProt Comments for PREPL
PREPL: Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Defects in PREPL are a cause of hypotonia-cystinuria syndrome (HCS). HCS is characterized generalized hypotonia at birth, nephrolithiasis, growth hormone deficiency, minor facial dysmorphism, failure to thrive, followed by hyperphagia and rapid weight gain in late childhood. HCS is caused by a deletion that disrups both SLC3A1 and PREPL genes. As SLC3A1 is known to cause isolated cystinuria type I, the extended phenotype could be attributed to the deletion of PREPL. Belongs to the peptidase S9A family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: Golgi apparatus; cytoskeleton; cytosol

Molecular Function: serine-type endopeptidase activity

Biological Process: proteolysis

Disease: Hypotonia-cystinuria Syndrome
Product References and Citations for anti-PREPL antibody
Parvari, R., et al. Genomics 86(2):195-211(2005)
Kim, D.K., et al. Biochim. Biophys. Acta 1565(1):112-121(2002)
Parvari, R., et al. Am. J. Hum. Genet. 69(4):869-875(2001)
Robertson, N.G., et al. Genomics 23(1):42-50(1994)

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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