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anti-B3GAT3 antibody :: Rabbit B3GAT3 Polyclonal Antibody

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Catalog # MBS9209328
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Western Blot (WB)
Product Name

B3GAT3, Polyclonal Antibody

Popular Item
Also Known As

B3GAT3 Antibody (C-term)

Product Synonym Names
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; Beta-1,3-glucuronyltransferase 3; Glucuronosyltransferase I; GlcAT-I; UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase; GlcUAT-I; B3GAT3
Antibody/Peptide Pairs
B3GAT3 peptide (MBS9218810) is used for blocking the activity of B3GAT3 antibody (MBS9209328)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
293-321
Immunogen Sequence Length
315
OMIM
245600
3D Structure
ModBase 3D Structure for O94766
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Hamster, Mouse)
Specificity
This B3GAT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human B3GAT3.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-B3GAT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-B3GAT3 antibody
The protein encoded by this gene is a member of the
glucuronyltransferase gene family, enzymes that exhibit strict
acceptor specificity, recognizing nonreducing terminal sugars and
their anomeric linkages. This gene product catalyzes the formation
of the glycosaminoglycan-protein linkage by way of a glucuronyl
transfer reaction in the final step of the biosynthesis of the
linkage region of proteoglycans.
Applications Tested/Suitable for anti-B3GAT3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-B3GAT3 antibody
WB~~1:1000

Western Blot (WB) of anti-B3GAT3 antibody
B3GAT3 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the B3GAT3 antibody detected the B3GAT3 protein (arrow).
anti-B3GAT3 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for B3GAT3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37122
NCBI Official Full Name
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform 1
NCBI Official Synonym Full Names
beta-1,3-glucuronyltransferase 3
NCBI Official Symbol
B3GAT3  [Similar Products]
NCBI Official Synonym Symbols
GLCATI; glcUAT-I
  [Similar Products]
NCBI Protein Information
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
UniProt Protein Name
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
UniProt Synonym Protein Names
Beta-1,3-glucuronyltransferase 3; Glucuronosyltransferase I; GlcAT-I; UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase; GlcUAT-I
UniProt Gene Name
B3GAT3  [Similar Products]
UniProt Synonym Gene Names
GlcAT-I; GlcUAT-I  [Similar Products]
UniProt Entry Name
B3GA3_HUMAN
NCBI Summary for B3GAT3
The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans. A pseudogene of this gene has been identified on chromosome 3. [provided by RefSeq, Dec 2013]
UniProt Comments for B3GAT3
B3GAT3: Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Defects in B3GAT3 are the cause of multiple joint dislocations short stature craniofacial dysmorphism and congenital heart defects (JDSSDHD). An autosomal recessive disease characterized by dysmorphic facies, bilateral dislocations of the elbows, hips, and knees, clubfeet, and short stature, as well as cardiovascular defects. Belongs to the glycosyltransferase 43 family.

Protein type: Membrane protein, integral; Transferase; EC 2.4.1.135; Glycan Metabolism - chondroitin sulfate biosynthesis; Glycan Metabolism - heparan sulfate biosynthesis

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: Golgi membrane; Golgi apparatus; cis-Golgi network; membrane; integral to membrane

Molecular Function: protein binding; glucuronosyltransferase activity; metal ion binding; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity

Biological Process: chondroitin sulfate metabolic process; positive regulation of catalytic activity; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; heparan sulfate proteoglycan biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; protein amino acid glycosylation; pathogenesis; dermatan sulfate proteoglycan biosynthetic process

Disease: Multiple Joint Dislocations, Short Stature, Craniofacial Dysmorphism, And Congenital Heart Defects
Product References and Citations for anti-B3GAT3 antibody
Tone, Y., et al. J. Biol. Chem. 283(24):16801-16807(2008)
Fondeur-Gelinotte, M., et al. Glycobiology 17(8):857-867(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Gulberti, S., et al. J. Biol. Chem. 280(2):1417-1425(2005)
Venkatesan, N., et al. Proc. Natl. Acad. Sci. U.S.A. 101(52):18087-18092(2004)

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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