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anti-ATR antibody :: Rabbit ATR Polyclonal Antibody

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Catalog # MBS222382
Unit / Price
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  0.1 mL  /  $550 +1 FREE 8GB USB
anti-ATR antibody
Product Name

ATR, Polyclonal Antibody

Full Product Name

RABBIT ANTI ATR (aa2381-2644)

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
210600
3D Structure
ModBase 3D Structure for Q13535
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Hamster, Mouse
Specificity
This item recognises the ATR (Ataxia telangiectasia and rad 3 related) protein, a 300kD protein kinase reported to have a role in recognising and responding to DNA strand interruptions during meiosis.This item cross-reacts with the related DNA-Pkcs.
Form/Format
Serum
Serum - liquid
Perservative Stabilisers
0.09% Sodium Azide
Immunogen
Human ATR peptide, amino acids 2381-2644
Antiserum Preparation
Antisera to human ATR peptide were raised by repeated immunisation of rabbits with highly purified antigen.
Target Species
Human
Preparation and Storage
Store at 4 degree C for one month or at -20 degree C for longer. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-ATR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ATR antibody
MBS222382 recognises the ATR (Ataxia telangiectasia and rad 3 related) protein, a 300kD protein kinase reported to have a role in recognising and responding to DNA strand interruptions during meiosis. MBS222382 cross-reacts with the related DNA-Pkcs.
Applications Tested/Suitable for anti-ATR antibody
Western Blot (WB)
Application Notes for anti-ATR antibody
Western Blotting: Maximum Dilution: 1/2000
NCBI/Uniprot data below describe general gene information for ATR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
297,479 Da
NCBI Official Full Name
serine/threonine-protein kinase ATR
NCBI Official Synonym Full Names
ATR serine/threonine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
FRP1; MEC1; SCKL; FCTCS; SCKL1
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NCBI Protein Information
serine/threonine-protein kinase ATR; FRAP-related protein-1; MEC1, mitosis entry checkpoint 1, homolog; ataxia telangiectasia and Rad3-related protein
UniProt Protein Name
Serine/threonine-protein kinase ATR
UniProt Synonym Protein Names
Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
ATR_HUMAN
NCBI Summary for ATR
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]
UniProt Comments for ATR
ATR: a ser/thr kinase of the PIKK family most closely related to ATM. Activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]Q. Phosphorylates BRCA1, Chk1, MCM2, RAD17, RPA2, SMC1 and p53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Protein type: Kinase, lipid; Membrane protein, integral; Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; ATYPICAL group; PIKK family; ATR subfamily

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: nucleoplasm; XY body; Golgi apparatus; PML body; chromosome

Molecular Function: protein dimerization activity; protein serine/threonine kinase activity; protein binding; DNA binding; MutLalpha complex binding; MutSalpha complex binding; ATP binding; protein kinase activity

Biological Process: response to drug; protein amino acid autophosphorylation; multicellular organismal development; cell cycle; DNA repair; double-strand break repair via homologous recombination; peptidyl-serine phosphorylation; negative regulation of DNA replication; regulation of protein binding; DNA damage checkpoint; positive regulation of DNA damage response, signal transduction by p53 class mediator; DNA replication; response to DNA damage stimulus

Disease: Seckel Syndrome 1; Cutaneous Telangiectasia And Cancer Syndrome, Familial
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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