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anti-A2M antibody :: Goat anti-Horse Alpha 2-Macroglobulin Polyclonal Antibody

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Catalog # MBS560170
Unit / Price
  0.1 mg  /  $250 +1 FREE 8GB USB
anti-A2M antibody
Product Name

Alpha 2-Macroglobulin (A2M), Polyclonal Antibody

Popular Item
Also Known As

Affinity Purified Goat anti-Horse Alpha 2 Macroglobulin

Product Synonym Names
Affinity Purified Goat anti-Horse Alpha 2-Macroglobulin; anti-Horse Alpha 2-Macroglobulin
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (9220304..9268558, complement). Location: 12p13.31
OMIM
103950
3D Structure
ModBase 3D Structure for P01023
Clonality
Polyclonal
Host
Goat
Species Reactivity
Horse
Purity/Purification
Unconjugated A.P.
Form/Format
Liquid
Buffer
Phosphate buffered saline, pH 7.2
Preservative
0.1% sodium azide
Procedure
Goats were immunized with horse macroglobulin. The goats were bled, serum collected then passed over serum protein immunoabsorbant columns lacking alpha 2 macroglobulin. The anti- A2M was immunoaffinity purified off an antigen containing immunoabsorbant.
Preparation and Storage
Store at 4 degree C.
Shelf Life: 12 months after shipping date
Other Notes
Small volumes of anti-A2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-A2M antibody
Goats were immunized with horse macroglobulins. The resulting antiserum was passed over an antigen containing immunoabsorbant from which the anti-horse macroglobulins were immunoaffinity purified.
Product Categories/Family for anti-A2M antibody
Application Notes for anti-A2M antibody
This product reacts with alpha 2 macroglobulin in serum. It does not react with horse IgM, IgA, IgG or IgG(T) by IEP analysis.
NCBI/Uniprot data below describe general gene information for A2M. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
163,291 Da[Similar Products]
NCBI Official Full Name
alpha-2-macroglobulin
NCBI Official Synonym Full Names
alpha-2-macroglobulin
NCBI Official Symbol
NCBI Official Synonym Symbols
A2MD; CPAMD5; FWP007; S863-7; DKFZp779B086
  [Similar Products]
NCBI Protein Information
alpha-2-macroglobulin; alpha-2-M; OTTHUMP00000196829; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
UniProt Protein Name
Alpha-2-macroglobulin
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CPAMD5  [Similar Products]
UniProt Entry Name
A2MG_HUMAN
NCBI Summary for A2M
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq]
UniProt Comments for A2M
A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.

Protein type: Inhibitor; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: extracellular region; cytosol

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding

Biological Process: negative regulation of complement activation, lectin pathway; extracellular matrix disassembly; platelet activation; regulation of small GTPase mediated signal transduction; extracellular matrix organization and biogenesis; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway

Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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