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anti-RNASEL antibody :: Rabbit anti-Human 2-5A-dependent ribonuclease Polyclonal Antibody

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Catalog # MBS1491439
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
anti-RNASEL antibody
Product Name

2-5A-dependent ribonuclease (RNASEL), Polyclonal Antibody

Full Product Name

Rabbit anti-human 2-5A-dependent ribonuclease polyclonal Antibody, Biotin conjugated

Product Synonym Names
2-5A-dependent RNase; Ribonuclease 4; Ribonuclease L; RNase L; RNASEL; RNS4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
176807
3D Structure
ModBase 3D Structure for Q05823
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Biotin
Immunogen
Recombinant human 2-5A-dependent ribonuclease protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22871 / sc-22870 / sc-25798
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-RNASEL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RNASEL antibody
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover.
Applications Tested/Suitable for anti-RNASEL antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for RNASEL. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
73,416 Da[Similar Products]
NCBI Official Full Name
2-5A-dependent ribonuclease
NCBI Official Synonym Full Names
ribonuclease L
NCBI Official Symbol
RNASEL  [Similar Products]
NCBI Official Synonym Symbols
RNS4; PRCA1
  [Similar Products]
NCBI Protein Information
2-5A-dependent ribonuclease
UniProt Protein Name
2-5A-dependent ribonuclease
UniProt Synonym Protein Names
Ribonuclease 4; Ribonuclease L; RNase L
UniProt Gene Name
RNASEL  [Similar Products]
UniProt Synonym Gene Names
RNS4; 2-5A-dependent RNase; RNase L  [Similar Products]
UniProt Entry Name
RN5A_HUMAN
NCBI Summary for RNASEL
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]
UniProt Comments for RNASEL
RNASEL: a multifunctional enzyme that possesses protein kinase and endoribonuclease activity, Mediator of interferon action, which play a role in mediating resistance to virus infection and apoptosis. Might play a central role in the regulation of mRNA turnover.

Protein type: Ribonuclease; Kinase, protein; Protein kinase, Other; EC 3.1.26.-; Protein kinase, Ser/Thr (non-receptor); Other group; Other-Unique family

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: cytosol; mitochondrial matrix; nuclear matrix

Molecular Function: ATP binding; endoribonuclease activity; metal ion binding; protein binding; protein kinase activity; ribonucleoprotein binding; RNA binding; rRNA binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; fat cell differentiation; mRNA processing; negative regulation of viral genome replication; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of mRNA stability; rRNA processing; transmembrane transport

Disease: Prostate Cancer, Hereditary, 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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