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anti-OGDH antibody :: Rabbit anti-Human 2-oxoglutarate dehydrogenase Polyclonal Antibody

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Catalog # MBS1489446
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
anti-OGDH antibody
Product Name

2-oxoglutarate dehydrogenase (OGDH), Polyclonal Antibody

Full Product Name

Rabbit anti-human 2-oxoglutarate dehydrogenase, mitochondrial polyclonal Antibody, Biotin conjugated

Product Synonym Names
2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
613022
3D Structure
ModBase 3D Structure for Q02218
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Biotin
Immunogen
Recombinant human 2-oxoglutarate dehydrogenase, mitochondrial protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49589 / sc-49590 / sc-49591 / sc-67238
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-OGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-OGDH antibody
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
Applications Tested/Suitable for anti-OGDH antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for OGDH. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,180 Da
NCBI Official Full Name
2-oxoglutarate dehydrogenase, mitochondrial isoform 2
NCBI Official Synonym Full Names
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
NCBI Official Symbol
NCBI Official Synonym Symbols
E1k; OGDC; AKGDH
  [Similar Products]
NCBI Protein Information
2-oxoglutarate dehydrogenase, mitochondrial
UniProt Protein Name
2-oxoglutarate dehydrogenase, mitochondrial
UniProt Synonym Protein Names
2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase
UniProt Gene Name
UniProt Synonym Gene Names
OGDC-E1  [Similar Products]
UniProt Entry Name
ODO1_HUMAN
NCBI Summary for OGDH
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
UniProt Comments for OGDH
OGDH: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3). Belongs to the alpha-ketoglutarate dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; Oxidoreductase; Mitochondrial; Amino Acid Metabolism - tryptophan; EC 1.2.4.2; Carbohydrate Metabolism - citrate (TCA) cycle

Chromosomal Location of Human Ortholog: 7p14-p13

Cellular Component: cytosol; mitochondrial matrix; mitochondrial membrane; mitochondrion; oxoglutarate dehydrogenase complex

Molecular Function: chaperone binding; heat shock protein binding; metal ion binding; oxoglutarate dehydrogenase (succinyl-transferring) activity; thiamin pyrophosphate binding

Biological Process: 2-oxoglutarate metabolic process; cellular metabolic process; cerebellar cortex development; generation of precursor metabolites and energy; glycolysis; glyoxylate metabolic process; hippocampus development; lysine catabolic process; NADH metabolic process; pyramidal neuron development; striatum development; succinyl-CoA metabolic process; tangential migration from the subventricular zone to the olfactory bulb; thalamus development; tricarboxylic acid cycle

Disease: Alpha-ketoglutarate Dehydrogenase Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-OGDH antibody
 Reference Product  PubMed Publications
 DLST antibody  >1 publications with OGDH and DLST
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