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anti-PSMA3 antibody :: Rabbit anti-Human 20S Proteasome alpha3 Polyclonal Antibody

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Catalog # MBS9408505
Unit / Price
  0.1 mL  /  $320 +1 FREE 8GB USB
Product Name

20S Proteasome alpha3 (PSMA3), Polyclonal Antibody

Also Known As

20S Proteasome alpha3 antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
248
OMIM
176843
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Purified by antigen-affinity chromatography.
Form/Format
Supplied in 0.1M Tris-buffered saline with 20% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Immunogen Type
Recombinant protein
Immunogen Description
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 147 of 20S Proteasome alpha3
Target Name
20S Proteasome alpha3
Preparation and Storage
Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
Other Notes
Small volumes of anti-PSMA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PSMA3 antibody
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq]
Product Categories/Family for anti-PSMA3 antibody
Applications Tested/Suitable for anti-PSMA3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PSMA3 antibody
Western blotting: 1:500-1:3000
Immunohistochemistry: 1:100-1:500

Testing Data of anti-PSMA3 antibody
Sample (30 ug of whole cell lysate) A: Molt-4 12% SDS PAGE Primary antibody diluted at 1: 1000
anti-PSMA3 antibody Testing Data image
Immunohistochemistry (IHC) of anti-PSMA3 antibody
Immunohistochemical analysis of paraffin-embedded U87 xenograft, using 20S Proteasome alpha3 antibody at 1: 100 dilution.
anti-PSMA3 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PSMA3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,647 Da[Similar Products]
NCBI Official Full Name
Proteasome (prosome, macropain) subunit, alpha type, 3
NCBI Official Synonym Full Names
proteasome subunit alpha 3
NCBI Official Symbol
PSMA3  [Similar Products]
NCBI Official Synonym Symbols
HC8; PSC3
  [Similar Products]
NCBI Protein Information
proteasome subunit alpha type-3
UniProt Protein Name
Proteasome subunit alpha type-3
UniProt Synonym Protein Names
Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8
UniProt Gene Name
PSMA3  [Similar Products]
UniProt Synonym Gene Names
HC8; PSC8  [Similar Products]
UniProt Entry Name
PSA3_HUMAN
NCBI Summary for PSMA3
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for PSMA3
PSMA3: a proteasomal protein of the T1A peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. Two alternatively spliced isoforms have been identified.

Protein type: Protease; Proteasome complex; EC 3.4.25.1

Chromosomal Location of Human Ortholog: 14q23

Cellular Component: nucleoplasm; proteasome complex; proteasome core complex; cytoplasm; cytosol; nucleus

Molecular Function: threonine endopeptidase activity; protein binding

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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