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anti-5-HT-2A antibody :: Rabbit anti-Human 5-HT-2A Polyclonal Antibody

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Catalog # MBS9383307
Unit / Price
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  0.1 mL  /  $440 +1 FREE 8GB USB
  0.2 mL  /  $715 +1 FREE 8GB USB
Western blot
Product Name

5-HT-2A, Polyclonal Antibody

Full Product Name

5-HT-2A Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS9383307 Technical Datasheet
X57830 mRNA
3D Structure
ModBase 3D Structure for P28223
Species Reactivity
5-HT-2A Ab detects endogenous levels of total 5-HT-2A.
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
1.0mg/ml (lot specific)
A synthesized peptide derived from human 5-HT-2A.
For western blot, incubate membrane with diluted Ab in 5% w/v milk , 1X TBS, 0.1% Tween®20 at 4°C with gentle shaking, overnight
Other Notes
Small volumes of anti-5-HT-2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-5-HT-2A antibody
Western Blot (WB)

Western blot of anti-5-HT-2A antibody
Western blot analysis of 5-HT-2A using COLO205 whole cell lysates
anti-5-HT-2A antibody Western blot image
NCBI/Uniprot data below describe general gene information for 5-HT-2A. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,940 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2A isoform 1
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 2A
NCBI Official Symbol
HTR2A  [Similar Products]
NCBI Official Synonym Symbols
HTR2; 5-HT2A
  [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2A
UniProt Protein Name
5-hydroxytryptamine receptor 2A
UniProt Synonym Protein Names
Serotonin receptor 2A
UniProt Gene Name
HTR2A  [Similar Products]
UniProt Synonym Gene Names
HTR2; 5-HT-2; 5-HT-2A  [Similar Products]
NCBI Summary for 5-HT-2A
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for 5-HT-2A
5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q14.2

Cellular Component: dendrite; plasma membrane

Molecular Function: drug binding; neurotransmitter receptor activity; serotonin binding; serotonin receptor activity

Biological Process: cellular calcium ion homeostasis; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); phosphoinositide 3-kinase cascade; phospholipase C activation; positive regulation of phosphatidylinositol biosynthetic process; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; synaptic transmission

Disease: Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Major Depressive Disorder; Obsessive-compulsive Disorder; Schizophrenia
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