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Add To Compare List anti-ADCY1 antibody :: Rabbit anti-Human A Cyclase I Polyclonal Antibody Catalog # MBS9602044 Unit / Price 0.1 mL / $255 +1 FREE 8GB USB 0.2 mL / $295 +1 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name A Cyclase I (ADCY1), Polyclonal Antibody Popular Item Full Product Name A Cyclase I Antibody Product Synonym Names Adenylate cyclase 1, fetal brain, type I; 3', 5'-cyclic AMP synthetase; AC1; Adcy1; ADCY1_HUMAN; adenyl cyclase; Adenylate cyclase 1; adenylate cyclase 1 (brain); Adenylate cyclase type 1; Adenylate cyclase type I; Adenylyl cyclase 1; ATP pyrophosphate lyase; ATP pyrophosphate-lyase 1; Brain adenylate cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase; deafness, autosomal recessive 44; DFNB44 Product Gene Name anti-ADCY1 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP 3D Structure ModBase 3D Structure for Q08828 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human Specificity A Cyclase I antibody detects endogenous levels of total A Cyclase I Purity/Purification The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin. Form/Format LiquidPhosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Concentration 1mg/ml (lot specific) Immunogen A synthesized peptide derived from human A Cyclase I Subcellular Location Membrane. Tissue Specificity Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla. Predicted Cross Reactivity Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (100%) Conjugation Unconjugated Preparation and Storage Store at -20 degree C. Stable for 12 months from date of receipt. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Supply Chain Verification Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire. Other Notes Small volumes of anti-ADCY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-ADCY1 antibody Function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca2+/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).Subunit Structure: Interacts with CALM.Post-translational Modifications: N-glycosylated.Similarity: The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Applications Tested/Suitable for anti-ADCY1 antibody Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) Application Notes for anti-ADCY1 antibody WB: 1:1000IF/ICC: 1:100-1:500 Immunofluorescence (IF) of anti-ADCY1 antibody MBS9602044 staining COLO205 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western Blot (WB) of anti-ADCY1 antibody Western blot analysis of A Cyclase I using COLO205 whole cell lysates TOP NCBI/Uniprot data below describe general gene information for ADCY1. It may not necessarily be applicable to this product. NCBI GI # 31083193 NCBI GeneID 107 NCBI Accession # NP_066939.1 [Other Products] NCBI GenBank Nucleotide # NM_021116.3 [Other Products] UniProt Primary Accession # Q08828 [Other Products] UniProt Secondary Accession # Q75MI1; A4D2L8[Other Products] UniProt Related Accession # Q08828[Other Products] Molecular Weight Observed: 130 kDaPredicted: 124 kDa TOP NCBI Official Full Name adenylate cyclase type 1 isoform 1 NCBI Official Synonym Full Names adenylate cyclase 1 NCBI Official Symbol ADCY1 [Similar Products] NCBI Official Synonym Symbols AC1; DFNB44 [Similar Products] NCBI Protein Information adenylate cyclase type 1 UniProt Protein Name Adenylate cyclase type 1 UniProt Synonym Protein Names ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase Protein Family Adenylate cyclase UniProt Gene Name ADCY1 [Similar Products] TOP NCBI Summary for ADCY1 This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] TOP UniProt Comments for ADCY1 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca2+/calmodulin levels (). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (). Research Articles on ADCY1 1. data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain. 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TOP Products associated with anti-ADCY1 antibody Reference Product PubMed Publications DRD4 antibody >2 publications with ADCY1 and DRD4 ADCY2 antibody >2 publications with ADCY1 and ADCY2 Pathways associated with anti-ADCY1 antibody Products by Pathway Pathway Diagram Activation Of GABAB Receptors Pathway antibodies Activation Of GABAB Receptors Pathway Diagram Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram Adenylate Cyclase Activating Pathway antibodies Adenylate Cyclase Activating Pathway Diagram Adenylate Cyclase Inhibitory Pathway antibodies Adenylate Cyclase Inhibitory Pathway Diagram Amoebiasis Pathway antibodies Amoebiasis Pathway Diagram Amoebiasis Pathway antibodies Amoebiasis Pathway Diagram Aquaporin-mediated Transport Pathway antibodies Aquaporin-mediated Transport Pathway Diagram Bile Secretion Pathway antibodies Bile Secretion Pathway Diagram Bile Secretion Pathway antibodies Bile Secretion Pathway Diagram CREB Phosphorylation Through The Activation Of Adenylate Cyclase Pathway antibodies CREB Phosphorylation Through The Activation Of Adenylate Cyclase Pathway Diagram Diseases associated with anti-ADCY1 antibody Disease Name Pubmed Publications Neoplasms Antibodies >1 publications with ADCY1 and Neoplasms Nervous System Diseases Antibodies >1 publications with ADCY1 and Nervous System Diseases Organs/Tissues associated with anti-ADCY1 antibody Organ/Tissue Name Pubmed Publications Eye Antibodies >6 publications with ADCY1 and Eye Brain Antibodies >6 publications with ADCY1 and Brain Embryonic Tissue Antibodies >3 publications with ADCY1 and Embryonic Tissue Nerve Antibodies >2 publications with ADCY1 and Nerve Kidney Antibodies >2 publications with ADCY1 and Kidney Bone Antibodies >1 publications with ADCY1 and Bone Heart Antibodies >1 publications with ADCY1 and Heart TOP © 2006-18 MyBioSource.com. 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