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anti-ADCY1 antibody :: Rabbit anti-Human A Cyclase I Polyclonal Antibody

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Catalog # MBS9602044
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

A Cyclase I (ADCY1), Polyclonal Antibody

Popular Item
Also Known As

A Cyclase I Antibody

Product Synonym Names
Adenylate cyclase 1, fetal brain, type I; 3', 5'-cyclic AMP synthetase; AC1; Adcy1; ADCY1_HUMAN; adenyl cyclase; Adenylate cyclase 1; adenylate cyclase 1 (brain); Adenylate cyclase type 1; Adenylate cyclase type I; Adenylyl cyclase 1; ATP pyrophosphate lyase; ATP pyrophosphate-lyase 1; Brain adenylate cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase; deafness, autosomal recessive 44; DFNB44
Product Gene Name

anti-ADCY1 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Immunogen Sequence Length
1119
3D Structure
ModBase 3D Structure for Q08828
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
A Cyclase I antibody detects endogenous levels of total A Cyclase I
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human A Cyclase I
Subcellular Location
Membrane.
Tissue Specificity
Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-ADCY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-ADCY1 antibody
Function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca2+/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).
Subunit Structure: Interacts with CALM.
Post-translational Modifications: N-glycosylated.
Similarity: The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Applications Tested/Suitable for anti-ADCY1 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-ADCY1 antibody
WB: 1:1000
IF/ICC: 1:100-1:500
Immunofluorescence (IF) of anti-ADCY1 antibody
MBS9602044 staining COLO205 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
anti-ADCY1 antibody Immunofluorescence (IF) image
Western Blot (WB) of anti-ADCY1 antibody
Western blot analysis of A Cyclase I using COLO205 whole cell lysates
anti-ADCY1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ADCY1. It may not necessarily be applicable to this product.
NCBI GI #
31083193
NCBI GeneID
107
NCBI Accession #
NP_066939.1 [Other Products]
NCBI GenBank Nucleotide #
NM_021116.3 [Other Products]
UniProt Primary Accession #
Q08828 [Other Products]
UniProt Secondary Accession #
Q75MI1; A4D2L8[Other Products]
UniProt Related Accession #
Q08828[Other Products]
Molecular Weight
Observed: 130 kDa
Predicted: 124 kDa
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NCBI Official Full Name
adenylate cyclase type 1 isoform 1
NCBI Official Synonym Full Names
adenylate cyclase 1
NCBI Official Symbol
ADCY1  [Similar Products]
NCBI Official Synonym Symbols
AC1; DFNB44
  [Similar Products]
NCBI Protein Information
adenylate cyclase type 1
UniProt Protein Name
Adenylate cyclase type 1
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase
Protein Family
Adenylate cyclase
UniProt Gene Name
ADCY1  [Similar Products]
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NCBI Summary for ADCY1
This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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UniProt Comments for ADCY1
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca2+/calmodulin levels (). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina ().
Research Articles on ADCY1
1. data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated withanti-ADCY1 antibody
 Reference Product  PubMed Publications
 DRD4 antibody  >2 publications with ADCY1 and DRD4
 ADCY2 antibody  >2 publications with ADCY1 and ADCY2
Pathways associated with anti-ADCY1 antibody
 Products by Pathway  Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adenylate Cyclase Activating Pathway antibodies  Adenylate Cyclase Activating Pathway Diagram
 Adenylate Cyclase Inhibitory Pathway antibodies  Adenylate Cyclase Inhibitory Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 CREB Phosphorylation Through The Activation Of Adenylate Cyclase Pathway antibodies  CREB Phosphorylation Through The Activation Of Adenylate Cyclase Pathway Diagram
Diseases associated with anti-ADCY1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with ADCY1 and Neoplasms
 Nervous System Diseases Antibodies  >1 publications with ADCY1 and Nervous System Diseases
Organs/Tissues associated with anti-ADCY1 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >6 publications with ADCY1 and Eye
 Brain Antibodies  >6 publications with ADCY1 and Brain
 Embryonic Tissue Antibodies  >3 publications with ADCY1 and Embryonic Tissue
 Nerve Antibodies  >2 publications with ADCY1 and Nerve
 Kidney Antibodies  >2 publications with ADCY1 and Kidney
 Bone Antibodies  >1 publications with ADCY1 and Bone
 Heart Antibodies  >1 publications with ADCY1 and Heart
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