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anti-ADAM8 antibody :: Rabbit anti-Human A Disintegrin And Metalloprotease 8 Polyclonal Antibody

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Catalog # MBS2027736 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $105 +1 FREE 8GB USB
  0.02 mg  /  $125 +1 FREE 8GB USB
  0.05 mg  /  $165 +1 FREE 8GB USB
  0.1 mg  /  $210 +1 FREE 8GB USB
  0.2 mg  /  $310 +1 FREE 8GB USB
  1 mg  /  $725 +1 FREE 8GB USB
Western Blot (WB)
Product Name

A Disintegrin And Metalloprotease 8 (ADAM8), Polyclonal Antibody

Also Known As

Polyclonal Antibody to A Disintegrin And Metalloprotease 8 (ADAM8)

Matching Pairs
Unconjugated Antibody: A Disintegrin And Metalloprotease 8 (MBS2027736)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
Matching Pairs
Unconjugated Antibody: A Disintegrin And Metalloprotease 8 (MBS2027736)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
824
Immunogen Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-SFP RMFSDCS QAYLESFLER PQSVCLANAP DLSHLVGGPV CGNLFVERGE QCDCGPPEDC RNRCCNSTTC QLAEGAQCAH GTCCQECKVK PAGELCRPKK DMCDLEEFCD GRHPECPEDA FQENGTPCSG GYCYNGACPT LAQQCQAFWG PGGQAAEESC FSYDILPGCK
OMIM
D26579 mRNA
3D Structure
ModBase 3D Structure for P78325
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody is a rabbit polyclonal antibody raised against ADAM8. It has beenselected for its ability to recognize ADAM8 in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Liquid
Concentration
200ug/ml (lot specific)
Fragment
ADAM8 (Ser371~Glu587)
Organism Species
Homo sapiens (Human)
Conjugate
No Conjugate
Immunogen
Recombinant ADAM8 (Ser371~Glu587) expressed in E Coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2045095
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-ADAM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ADAM8 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-ADAM8 antibody
Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-ADAM8 antibody
Western Blot: Sample: Recombinant protein.
anti-ADAM8 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ADAM8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,262 Da
NCBI Official Full Name
disintegrin and metalloproteinase domain-containing protein 8 isoform 1
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 8
NCBI Official Symbol
ADAM8  [Similar Products]
NCBI Official Synonym Symbols
MS2; CD156; CD156a
  [Similar Products]
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 8
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 8
UniProt Synonym Protein Names
Cell surface antigen MS2; CD_antigen: CD156a
UniProt Gene Name
ADAM8  [Similar Products]
UniProt Synonym Gene Names
MS2; ADAM 8  [Similar Products]
NCBI Summary for ADAM8
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
UniProt Comments for ADAM8
ADAM8: Possible involvement in extravasation of leukocytes.

Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: alpha9-beta1 integrin-ADAM8 complex; cell surface; cytoplasm; dense core granule membrane; integral component of plasma membrane; plasma membrane; podosome; specific granule

Molecular Function: calcium ion binding; cell adhesion molecule binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; protein self-association; serine-type endopeptidase activity; zinc ion binding

Biological Process: angiogenesis; cell morphogenesis; cellular response to hypoxia; extracellular matrix disassembly; inflammatory response; leukocyte migration involved in inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; neutrophil degranulation; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of eosinophil migration; positive regulation of fibronectin-dependent thymocyte migration; positive regulation of innate immune response; positive regulation of MAP kinase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of neutrophil extravasation; positive regulation of NF-kappaB transcription factor activity; positive regulation of protein kinase B signaling; positive regulation of protein processing; positive regulation of protein secretion; positive regulation of T cell differentiation in thymus; positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; proteolysis; regulation of cell-cell adhesion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-ADAM8 antibody
 Reference Product  PubMed Publications
 IL13 antibody  >2 publications with ADAM8 and IL13
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