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anti-ADAMTS12 antibody :: Rabbit anti-Human A Disintegrin And Metalloproteinase With Thrombospondin 12 Polyclonal Antibody

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Catalog # MBS2027021 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $115 +1 FREE 8GB USB
  0.02 mg  /  $135 +1 FREE 8GB USB
  0.05 mg  /  $190 +1 FREE 8GB USB
  0.1 mg  /  $245 +1 FREE 8GB USB
  0.2 mg  /  $370 +1 FREE 8GB USB
  1 mg  /  $875 +1 FREE 8GB USB
Product Name

A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12), Polyclonal Antibody

Also Known As

Polyclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1594
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- QQMYFWQY GHWTECSVTC GTGIRRQTAH CIKKGRGMVK ATFCDPETQP NGRQKKCHEK ACPPRWWAGE WEACSATCGP HGEKKRTVLC IQTMVSDEQA LPPTDCQHLL KPKTLLSCNR DILCPSDWTV GNWSECSVSC GGGVRIRSVT CAKNHDEPCD VTRKPNSRAL CGLQQCP
OMIM
AJ250725 mRNA
3D Structure
ModBase 3D Structure for P58397
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody is a rabbit polyclonal antibody raised against ADAMTS12. It has beenselected for its ability to recognize ADAMTS12 in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Liquid
Concentration
200ug/ml (lot specific)
Fragment
ADAMTS12 (Gln823~Pro997)
Organism Species
Homo sapiens (Human)
Conjugate
No Conjugate
Immunogen
Recombinant ADAMTS12 (Gln823~Pro997) expressed in E Coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2084425
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-ADAMTS12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ADAMTS12 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)
Application Notes for anti-ADAMTS12 antibody
Western blotting: 0.2-2ug/mL;1:250-2500
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-ADAMTS12 antibody
Western Blot: Sample: Recombinant protein.
anti-ADAMTS12 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ADAMTS12 antibody
DAB staining on fromalin fixed paraffin-embedded Stomach tissue)
anti-ADAMTS12 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ADAMTS12. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
168,460 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform 2
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif 12
NCBI Official Symbol
ADAMTS12  [Similar Products]
NCBI Official Synonym Symbols
PRO4389
  [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Gene Name
ADAMTS12  [Similar Products]
UniProt Synonym Gene Names
ADAM-TS 12; ADAM-TS12; ADAMTS-12  [Similar Products]
NCBI Summary for ADAMTS12
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS12
ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5p13.3-p13.2

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: metalloendopeptidase activity; protein binding; zinc ion binding

Biological Process: cell migration; cell-matrix adhesion; cellular response to BMP stimulus; cellular response to interleukin-1; cellular response to tumor necrosis factor; negative regulation of cellular response to hepatocyte growth factor stimulus; negative regulation of cellular response to vascular endothelial growth factor stimulus; negative regulation of chondrocyte differentiation; negative regulation of hepatocyte growth factor receptor signaling pathway; proteoglycan catabolic process; proteolysis involved in cellular protein catabolic process; regulation of endothelial tube morphogenesis; regulation of inflammatory response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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