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anti-AKAP5 antibody :: Rabbit anti-Human A-kinase anchor protein 5 Polyclonal Antibody

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Catalog # MBS1496382
Unit / Price
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  0.05 mL  /  $120 +1 FREE 8GB USB
  0.1 mL  /  $160 +1 FREE 8GB USB
Product Name

A-kinase anchor protein 5 (AKAP5), Polyclonal Antibody

Full Product Name

Rabbit anti-human A-kinase anchor protein 5 polyclonal Antibody(AKAP5)

Product Synonym Names
AKAP-5; A-kinase anchor protein 79 kDa; AKAP 79; H21; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; AKAP5; AKAP79
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
604688
3D Structure
ModBase 3D Structure for P24588
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human A-kinase anchor protein 5 protein (1-270aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6442 / sc-10764
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-AKAP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AKAP5 antibody
May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.
Applications Tested/Suitable for anti-AKAP5 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-AKAP5 antibody
Recommended dilution: IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-AKAP5 antibody
Immunohistochemistry of paraffin-embedded human rectum using MBS1496382 at dilution 1:100
anti-AKAP5 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-AKAP5 antibody
Immunohistochemistry of paraffin-embedded human colon cancer using MBS1496382 at dilution 1:100
anti-AKAP5 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for AKAP5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,088 Da
NCBI Official Full Name
A-kinase anchor protein 5
NCBI Official Synonym Full Names
A-kinase anchoring protein 5
NCBI Official Symbol
AKAP5  [Similar Products]
NCBI Official Synonym Symbols
H21; AKAP75; AKAP79
  [Similar Products]
NCBI Protein Information
A-kinase anchor protein 5
UniProt Protein Name
A-kinase anchor protein 5
UniProt Synonym Protein Names
A-kinase anchor protein 79 kDa; AKAP 79; H21; cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
Protein Family
UniProt Gene Name
AKAP5  [Similar Products]
UniProt Synonym Gene Names
AKAP79; AKAP-5; AKAP 79  [Similar Products]
UniProt Entry Name
AKAP5_HUMAN
NCBI Summary for AKAP5
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]
UniProt Comments for AKAP5
AKAP5: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C. Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q23.3

Cellular Component: asymmetric synapse; basolateral plasma membrane; cell soma; cytoskeleton; cytosol; dendritic shaft; dendritic spine; filopodium membrane; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; protein complex

Molecular Function: actin binding; adenylate cyclase binding; cadherin binding; calmodulin binding; G-protein-coupled receptor binding; GABA receptor binding; protein binding; protein complex binding; protein domain specific binding; protein kinase A binding; protein kinase binding; protein phosphatase 2B binding

Biological Process: cellular protein complex disassembly; energy reserve metabolic process; hippocampus development; maternal process involved in pregnancy; negative regulation of adenylate cyclase activity; negative regulation of potassium ion transport; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; positive regulation of dendrite morphogenesis; positive regulation of NFAT protein import into nucleus; positive regulation of protein amino acid phosphorylation; protein targeting; regulation of insulin secretion; response to electrical stimulus; response to muscle activity; signal transduction; spinal cord development; synaptic transmission
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-AKAP5 antibody
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