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anti-AADAC antibody :: Rabbit anti-Human AADAC Polyclonal Antibody

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Catalog # MBS9203843
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

AADAC, Polyclonal Antibody

Also Known As

AADAC Antibody (C-term)

Product Synonym Names
Arylacetamide deacetylase; AADAC; DAC
Antibody/Peptide Pairs
AADAC peptide (MBS9226350) is used for blocking the activity of AADAC antibody (MBS9203843)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
273-300
Immunogen Sequence Length
399
OMIM
600338
3D Structure
ModBase 3D Structure for P22760
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This AADAC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-300 amino acids from the C-terminal region of human AADAC.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-AADAC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AADAC antibody
Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
Applications Tested/Suitable for anti-AADAC antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-AADAC antibody
WB~~1:1000

Western Blot (WB) of anti-AADAC antibody
Western blot analysis of AADAC Antibody (C-term) in 293 cell line lysates (35ug/lane). AADAC (arrow) was detected using the purified Pab.
anti-AADAC antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-AADAC antibody
Formalin-fixed and paraffin-embedded human hepatocarcinoma with AADAC Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-AADAC antibody Immunohistochemistry (IHC) (IHC) image
Flow Cytometry (FC/FACS) of anti-AADAC antibody
Flow cytometric analysis of widr cells using AADAC Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-AADAC antibody Flow Cytometry (FC/FACS) (FC/FACS) image
Western Blot (WB) of anti-AADAC antibody
Western blot analysis of AADAC (arrow) using rabbit polyclonal AADAC Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the AADAC gene.
anti-AADAC antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for AADAC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45734
NCBI Official Full Name
arylacetamide deacetylase
NCBI Official Synonym Full Names
arylacetamide deacetylase
NCBI Official Symbol
AADAC  [Similar Products]
NCBI Official Synonym Symbols
DAC; CES5A1
  [Similar Products]
NCBI Protein Information
arylacetamide deacetylase
UniProt Protein Name
Arylacetamide deacetylase
Protein Family
UniProt Gene Name
AADAC  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
AAAD_HUMAN
NCBI Summary for AADAC
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
UniProt Comments for AADAC
AADAC: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. Belongs to the 'GDXG' lipolytic enzyme family.

Protein type: Endoplasmic reticulum; Deacetylase; Motility/polarity/chemotaxis; EC 3.1.1.3; Lipase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q25.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: deacetylase activity; triacylglycerol lipase activity; serine hydrolase activity; lipase activity; catalytic activity

Biological Process: metabolic process
Product References and Citations for anti-AADAC antibody
Saito,S., et.al., J. Hum. Genet. 48 (5), 249-270 (2003)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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