• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-AADAT antibody :: Rabbit anti-Human AADAT Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS9208970
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Western Blot (WB)
Product Name

AADAT, Polyclonal Antibody

Also Known As

AADAT Antibody (Center)

Product Synonym Names
Kynurenine/alpha-aminoadipate aminotransferase; mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; Alpha-aminoadipate aminotransferase; AadAT; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; Kynurenine--oxoglutarate transaminase II; AADAT; KAT2
Antibody/Peptide Pairs
AADAT peptide (MBS9217454) is used for blocking the activity of AADAT antibody (MBS9208970)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
196-224
Immunogen Sequence Length
425
OMIM
611754
3D Structure
ModBase 3D Structure for Q8N5Z0
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This AADAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the Central region of human AADAT.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-AADAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AADAT antibody
This gene encodes a protein that is highly similar to
mouse and rat kynurenine aminotransferase II. The rat protein is a
homodimer with two transaminase activities. One activity is the
transamination of alpha-aminoadipic acid, a final step in the
saccaropine pathway which is the major pathway for L-lysine
catabolism. The other activity involves the transamination of
kynurenine to produce kynurenine acid, the precursor of kynurenic
acid which has neuroprotective properties. Two alternative
transcripts encoding the same isoform have been identified,
however, additional alternative transcripts and isoforms may exist.
Applications Tested/Suitable for anti-AADAT antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-AADAT antibody
WB~~1:1000

Western Blot (WB) of anti-AADAT antibody
AADAT Antibody (Center) western blot analysis in HepG2,Y79 cell line lysates (35ug/lane).This demonstrates the AADAT antibody detected the AADAT protein (arrow).
anti-AADAT antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for AADAT. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47352
NCBI Official Full Name
kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform b
NCBI Official Synonym Full Names
aminoadipate aminotransferase
NCBI Official Symbol
AADAT  [Similar Products]
NCBI Official Synonym Symbols
KAT2; KATII
  [Similar Products]
NCBI Protein Information
kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
UniProt Protein Name
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
UniProt Synonym Protein Names
2-aminoadipate aminotransferase; 2-aminoadipate transaminase (EC:2.6.1.39); Alpha-aminoadipate aminotransferase; AadAT; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2 (EC:2.6.1.7); Kynurenine--oxoglutarate transaminase II
UniProt Gene Name
AADAT  [Similar Products]
UniProt Synonym Gene Names
KAT2; KAT/AadAT; AadAT  [Similar Products]
UniProt Entry Name
AADAT_HUMAN
NCBI Summary for AADAT
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
UniProt Comments for AADAT
AADAT: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.6.1.7; Amino Acid Metabolism - lysine degradation; Transferase; Amino Acid Metabolism - lysine biosynthesis; Mitochondrial; EC 2.6.1.39; Amino Acid Metabolism - tryptophan

Chromosomal Location of Human Ortholog: 4q33

Cellular Component: mitochondrial matrix

Molecular Function: protein homodimerization activity; kynurenine-oxoglutarate transaminase activity; 2-aminoadipate transaminase activity; pyridoxal phosphate binding

Biological Process: glutamate metabolic process; tryptophan catabolic process to kynurenine; L-lysine catabolic process to acetyl-CoA via saccharopine; lysine catabolic process; biosynthetic process; tryptophan catabolic process; 2-oxoglutarate metabolic process
Product References and Citations for anti-AADAT antibody
Han, Q., et al. Biosci. Rep. 28(4):205-215(2008)
Rossi, F., et al. J. Biol. Chem. 283(6):3559-3566(2008)
Han, Q., et al. J. Biol. Chem. 283(6):3567-3573(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Goh, D.L., et al. Mol. Genet. Metab. 76(3):172-180(2002)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-AADAT antibody
Organs/Tissues associated with anti-AADAT antibody
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000