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anti-ABCA2 antibody :: Rabbit anti-Human ABCA2 Polyclonal Antibody

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Catalog # MBS9201906
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ABCA2, Polyclonal Antibody

Also Known As

ABCA2 Antibody (Center)

Product Synonym Names
ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; ABCA2; ABC2; KIAA1062
Antibody/Peptide Pairs
ABCA2 peptide (MBS9229692) is used for blocking the activity of ABCA2 antibody (MBS9201906)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
2436
OMIM
600047
3D Structure
ModBase 3D Structure for Q9BZC7
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This ABCA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1339-1373 amino acids from the Central region of human ABCA2.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ABCA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCA2 antibody
Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.
Applications Tested/Suitable for anti-ABCA2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ABCA2 antibody
WB~~1:1000

Western Blot (WB) of anti-ABCA2 antibody
Western blot analysis of lysate from U-87 MG cell line, using ABCA2 Antibody (Center). MBS9201906 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
anti-ABCA2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ABCA2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
269873
NCBI Official Full Name
ATP-binding cassette sub-family A member 2 isoform a
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family A (ABC1), member 2
NCBI Official Symbol
ABCA2  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
ATP-binding cassette sub-family A member 2
UniProt Protein Name
ATP-binding cassette sub-family A member 2
UniProt Synonym Protein Names
ATP-binding cassette transporter 2; ATP-binding cassette 2
Protein Family
UniProt Gene Name
ABCA2  [Similar Products]
UniProt Synonym Gene Names
ABC2; KIAA1062; ATP-binding cassette 2  [Similar Products]
UniProt Entry Name
ABCA2_HUMAN
NCBI Summary for ABCA2
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCA2
ABCA2: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. Belongs to the ABC transporter superfamily. ABCA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: membrane; lysosome; lysosomal membrane; cytoplasmic membrane-bound vesicle; integral to membrane; microtubule organizing center; endosome membrane; ATP-binding cassette (ABC) transporter complex; endosome

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATPase activity; nucleotide binding; ATP binding

Biological Process: response to drug; regulation of transcription from RNA polymerase II promoter; cholesterol homeostasis; response to steroid hormone stimulus; transport; lipid metabolic process; transmembrane transport; regulation of intracellular cholesterol transport
Product References and Citations for anti-ABCA2 antibody
Kaminski W.E.,et al.Biochem. Biophys. Res. Commun. 281:249-258(2001).
Vulevic B.,et al.Cancer Res. 61:3339-3347(2001).
Humphray S.J.,et al.Nature 429:369-374(2004).
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Nakajima D.,et al.DNA Res. 9:99-106(2002).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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