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anti-ABCA7 antibody :: Rabbit anti-Human ABCA7 Polyclonal Antibody

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Catalog # MBS150228
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

ABCA7, Polyclonal Antibody

Popular Item
Also Known As

ABCA7 Antibody

Product Synonym Names
ABCX; ABCA-SSN; ATP-binding cassette sub-family A member 7; ATP-binding cassette, sub-family A (ABC1), member 7
Antibody/Peptide Pairs
ABCA7 peptide (MBS152658) is used for blocking the activity of ABCA7 antibody (MBS150228)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
2146
OMIM
605414
3D Structure
ModBase 3D Structure for Q8IZY2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
ABCA7 antibody is human specific. At least two alternatively spliced transcript variants encoding distinct isoforms have been observed.
Purity/Purification
ABCA7 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
ABCA7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human ABCA7.
Buffer
ABCA7 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
ABCA7 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-ABCA7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCA7 antibody
ABCA7 Antibody: ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.
Applications Tested/Suitable for anti-ABCA7 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-ABCA7 antibody
ABCA7 antibody can be used for detection of ABCA7 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 5 mug/mL.

Western Blot (WB) of anti-ABCA7 antibody
Western blot analysis of ABCA7 in 293 cell lysate with ABCA7 antibody at (A) 1 and (B) 2 μg/mL.
anti-ABCA7 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-ABCA7 antibody
Immunofluorescence of ABCA7 in 293 cells with ABCA7 antibody at 20 μg/mL.
anti-ABCA7 antibody Immunofluorescence (IF) image
Immunocytochemistry (ICC) of anti-ABCA7 antibody
Immunocytochemistry of ABCA7 in 293 cells with ABCA7 antibody at 5 μg/mL.
anti-ABCA7 antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for ABCA7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
218,497 Da
NCBI Official Full Name
ATP-binding cassette sub-family A member 7
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family A (ABC1), member 7
NCBI Official Symbol
ABCA7  [Similar Products]
NCBI Official Synonym Symbols
ABCX; ABCA-SSN
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family A member 7; autoantigen SS-N; macrophage ABC transporter
UniProt Protein Name
ATP-binding cassette sub-family A member 7
UniProt Synonym Protein Names
ABCA-SSN; Autoantigen SS-N; Macrophage ABC transporter
Protein Family
UniProt Gene Name
ABCA7  [Similar Products]
UniProt Entry Name
ABCA7_HUMAN
NCBI Summary for ABCA7
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCA7
ABCA7: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: Golgi membrane; Golgi apparatus; cell surface; cytoplasm; apical plasma membrane; integral to membrane; plasma membrane; endosome membrane; ATP-binding cassette (ABC) transporter complex; phagocytic cup

Molecular Function: apolipoprotein A-I receptor activity; phospholipid transporter activity; transporter activity; ATPase activity; ATP binding

Biological Process: phospholipid efflux; positive regulation of ATPase activity; positive regulation of phagocytosis; negative regulation of amyloid precursor protein biosynthetic process; cholesterol efflux; peptide cross-linking; phospholipid scrambling; negative regulation of ATPase activity; transmembrane transport; phagocytosis; memory
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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