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anti-ABCB8 antibody :: Goat ABCB8 Polyclonal Antibody

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Catalog # MBS422177
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-ABCB8 antibody
Product Name

ABCB8, Polyclonal Antibody

Also Known As

Goat anti-ABCB8 Antibody

Product Synonym Names
ABCB8; ATP-binding cassette, sub-family B (MDR/TAP), member 8; EST328128; M-ABC1; MABC1; ATP-binding cassette, sub-family B, member 8; mitochondrial ABC protein; ABCB8 antibody; ATP-binding cassette; sub-family B (MDR/TAP); member 8 antibody; EST328128 antibody; M-ABC1 antibody; MABC1 antibody; ATP-binding cassette; sub-family B; member 8 antibody; mitochondrial ABC protein antibody
Antibody/Peptide Pairs
ABCB8 peptide (MBS426536) is used for blocking the activity of ABCB8 antibody (MBS422177)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
718
Immunogen Sequence
KKPEGPRSHQ HK
OMIM
605464
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-KKPEGPRSHQHK, from the C Terminus of the protein sequence according to NP_009119.2.
Epitope
C Terminus
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ABCB8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCB8 antibody
Peptide ELISA (EIA)
Application Notes for anti-ABCB8 antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Preliminary experiments gave an approx 22kDa band in lysates of cell lines HeLa and Jurkat after 0.5ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 78.1kDa according to NP_009119.2. The 22kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for ABCB8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,383 Da
NCBI Official Full Name
ATP-binding cassette sub-family B member 8, mitochondrial isoform b
NCBI Official Synonym Full Names
ATP binding cassette subfamily B member 8
NCBI Official Symbol
ABCB8  [Similar Products]
NCBI Official Synonym Symbols
MABC1; M-ABC1; EST328128
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family B member 8, mitochondrial
UniProt Protein Name
ATP-binding cassette sub-family B member 8, mitochondrial
UniProt Synonym Protein Names
Mitochondrial ATP-binding cassette 1; M-ABC1
UniProt Gene Name
ABCB8  [Similar Products]
UniProt Synonym Gene Names
MABC1; M-ABC1  [Similar Products]
UniProt Entry Name
ABCB8_HUMAN
NCBI Summary for ABCB8
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for ABCB8
ABCB8: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008]

Protein type: Hydrolase; Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: ATP-binding cassette (ABC) transporter complex; membrane; mitochondrial envelope; mitochondrial inner membrane; mitochondrion; nucleolus; nucleus

Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; transporter activity

Biological Process: metabolic process; transmembrane transport; transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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