NP_001229942.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
84,475 Da
NCBI Official Full Name
ATP-binding cassette sub-family B member 9 isoform 6
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family B (MDR/TAP), member 9
NCBI Protein Information
ATP-binding cassette sub-family B member 9; TAP-like protein; ABC transporter 9 protein
UniProt Protein Name
ATP-binding cassette sub-family B member 9
UniProt Synonym Protein Names
ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL
UniProt Synonym Gene Names
UniProt Entry Name
ABCB9_HUMAN
NCBI Summary for ABCB9
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]
UniProt Comments for ABCB9
Function: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Ref.11 Ref.12 Ref.16
Subunit structure: Homodimer. Ref.11
Subcellular location: Lysosome membrane; Multi-pass membrane protein. Note: May be located in membrane rafts. Ref.2 Ref.10 Ref.12 Ref.13 Ref.14 Ref.15 Ref.17 Ref.18
Tissue specificity: Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages. Ref.2 Ref.12
Induction: Not induced by interferon-gamma. Ref.1
Domain: The N-terminal region comprising the first four transmembrane domains is required for lysosomal localization but not for homodimerization or peptide transport. Ref.10 Ref.15 Ref.17
Sequence similarities: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. [View classification]Contains 1 ABC transmembrane type-1 domain.Contains 1 ABC transporter domain.
Caution: Has also been detected in the endoplasmic reticulum (Ref.1) but appears to be a lysosomal protein in vivo.
Biophysicochemical propertiesKinetic parameters:KM=6.8 µM for peptide RRYQNSTCL Ref.11pH dependence:Optimum pH is 7.0.Temperature dependence:Optimum temperature is 37 degrees Celsius.
Sequence caution: The sequence BAA96044.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence BAD66830.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Research Articles on ABCB9
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Products associated with anti-ABCB9 antibody
Pathways associated with anti-ABCB9 antibody
Organs/Tissues associated with anti-ABCB9 antibody
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