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anti-ABCC11 antibody :: Rabbit anti-Human ABCC11 Polyclonal Antibody

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Catalog # MBS9210064
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

ABCC11, Polyclonal Antibody

Also Known As

ABCC11 Antibody (N-term)

Product Synonym Names
ATP-binding cassette sub-family C member 11; Multidrug resistance-associated protein 8; ABCC11; MRP8
Antibody/Peptide Pairs
ABCC11 peptide (MBS9225369) is used for blocking the activity of ABCC11 antibody (MBS9210064)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
343-372
Immunogen Sequence Length
1,344
OMIM
117800
3D Structure
ModBase 3D Structure for Q96J66
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This ABCC11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-372 amino acids from the N-terminal region of human ABCC11.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ABCC11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCC11 antibody
ABCC11 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1.
Applications Tested/Suitable for anti-ABCC11 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ABCC11 antibody
WB~~1:1000

Western Blot (WB) of anti-ABCC11 antibody
Western blot analysis of ABCC11 Antibody (N-term) in WiDr cell line lysates (35ug/lane). ABCC11 (arrow) was detected using the purified Pab.
anti-ABCC11 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ABCC11 antibody
ABCC11 Antibody (N-term) IHC analysis in formalin fixed and paraffin embedded breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCC11 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-ABCC11 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ABCC11. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
154301
NCBI Official Full Name
ATP-binding cassette sub-family C member 11 isoform a
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
NCBI Official Symbol
ABCC11  [Similar Products]
NCBI Official Synonym Symbols
WW; EWWD; MRP8
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family C member 11
UniProt Protein Name
ATP-binding cassette sub-family C member 11
UniProt Synonym Protein Names
Multidrug resistance-associated protein 8
Protein Family
UniProt Gene Name
ABCC11  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
ABCCB_HUMAN
NCBI Summary for ABCC11
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC11
ABCC11: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, ABC family; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: purine nucleotide transmembrane transporter activity; ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding

Biological Process: metabolic process; purine nucleotide transport; transmembrane transport; organic anion transport

Disease: Apocrine Gland Secretion, Variation In
Product References and Citations for anti-ABCC11 antibody
Martin, A., et al. J. Invest. Dermatol. 130(2):529-540(2010)
J. Hum. Genet. 54(9):499-503(2009)
Sato, T., et al. J. Hum. Genet. 54(7):409-413(2009)

Research Articles on ABCC11
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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