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anti-ABCC3 antibody :: Rabbit anti-Human ABCC3 Polyclonal Antibody

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Catalog # MBS9207382
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

ABCC3, Polyclonal Antibody

Also Known As

ABCC3 Antibody (Center)

Product Synonym Names
Canalicular multispecific organic anion transporter 2; ATP-binding cassette sub-family C member 3; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3; ABCC3; CMOAT2; MLP2; MRP3
Antibody/Peptide Pairs
ABCC3 peptide (MBS9217445) is used for blocking the activity of ABCC3 antibody (MBS9207382)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
899-925
Immunogen Sequence Length
572
OMIM
604323
3D Structure
ModBase 3D Structure for O15438
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This ABCC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 899-925 amino acids from the Central region of human ABCC3.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ABCC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCC3 antibody
The protein encoded by this gene is a member of the
superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct
subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
protein is a member of the MRP subfamily which is involved in
multi-drug resistance. The specific function of this protein has
not yet been determined; however, this protein may play a role in
the transport of biliary and intestinal excretion of organic
anions. Alternatively spliced variants which encode different
protein isoforms have been described; however, not all variants
have been fully characterized.
Applications Tested/Suitable for anti-ABCC3 antibody
ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Western Blot (WB)
Application Notes for anti-ABCC3 antibody
WB~~1:1000

Western Blot (WB) of anti-ABCC3 antibody
ABCC3 Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the ABCC3 antibody detected the ABCC3 protein (arrow).
anti-ABCC3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ABCC3 antibody
ABCC3 antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCC3 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-ABCC3 antibody Immunohistochemistry (IHC) (IHC) image
Flow Cytometry (FC/FACS) of anti-ABCC3 antibody
ABCC3 Antibody (Center) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-ABCC3 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
NCBI/Uniprot data below describe general gene information for ABCC3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
169343
NCBI Official Full Name
canalicular multispecific organic anion transporter 2 isoform 2
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 3
NCBI Official Symbol
ABCC3  [Similar Products]
NCBI Official Synonym Symbols
MLP2; MRP3; ABC31; MOAT-D; cMOAT2; EST90757
  [Similar Products]
NCBI Protein Information
canalicular multispecific organic anion transporter 2
UniProt Protein Name
Canalicular multispecific organic anion transporter 2
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 3; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3
Protein Family
UniProt Gene Name
ABCC3  [Similar Products]
UniProt Synonym Gene Names
CMOAT2; MLP2; MRP3; MOAT-D  [Similar Products]
UniProt Entry Name
MRP3_HUMAN
NCBI Summary for ABCC3
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC3
ABCC3: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ABC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding

Biological Process: bile acid and bile salt transport; bile acid metabolic process; transport; transmembrane transport
Product References and Citations for anti-ABCC3 antibody
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Hoffman, A.D., et al. Protein J. 29(5):373-379(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Moyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(3):811-821(2010)

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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