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anti-ABCC5 antibody :: Rabbit anti-Human ABCC5 Polyclonal Antibody

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Catalog # MBS9131905
Unit / Price
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  0.05 mL  /  $200 +1 FREE 8GB USB
  0.1 mL  /  $275 +1 FREE 8GB USB
  0.2 mL  /  $430 +1 FREE 8GB USB
Product Name

ABCC5, Polyclonal Antibody

Full Product Name

ABCC5 Polyclonal Antibody

Product Synonym Names
ABC33; EST277145; MOAT-C; MOATC; MRP5; SMRP; pABC11
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AF104942 mRNA
3D Structure
ModBase 3D Structure for O15440
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity Purification
Immunogen
A synthetic peptide of human ABCC5
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-ABCC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCC5 antibody
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants.
Product Categories/Family for anti-ABCC5 antibody
Applications Tested/Suitable for anti-ABCC5 antibody
Western Blot (WB)
Application Notes for anti-ABCC5 antibody
WB: 1:500 - 2000

Western Blot (WB) of anti-ABCC5 antibody
Western blot analysis of extracts of HeLa cells, using ABCC5 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.
anti-ABCC5 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ABCC5 antibody
Immunohistochemistry of paraffin-embedded human breast cancer using ABCC5 antibody at dilution of 1:100 (40x lens).
anti-ABCC5 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ABCC5 antibody
Immunohistochemistry of paraffin-embedded human stomach using ABCC5 antibody at dilution of 1:100 (40x lens).
anti-ABCC5 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ABCC5 antibody
Immunohistochemistry of paraffin-embedded rat heart using ABCC5 antibody at dilution of 1:100 (40x lens).
anti-ABCC5 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ABCC5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
161kDa
NCBI Official Full Name
Multidrug resistance-associated protein 5
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 5
NCBI Official Symbol
ABCC5  [Similar Products]
NCBI Official Synonym Symbols
MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145
  [Similar Products]
NCBI Protein Information
multidrug resistance-associated protein 5
UniProt Protein Name
Multidrug resistance-associated protein 5
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP; pABC11
Protein Family
UniProt Gene Name
ABCC5  [Similar Products]
UniProt Synonym Gene Names
MRP5; MOAT-C  [Similar Products]
NCBI Summary for ABCC5
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
UniProt Comments for ABCC5
ABCC5: Acts as a multispecific organic anion pump which can transport nucleotide analogs. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: anion transmembrane-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity

Biological Process: hyaluronan biosynthetic process; transmembrane transport; transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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