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anti-ABCD1 antibody :: Goat ABCD1 Polyclonal Antibody

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Catalog # MBS420795
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ABCD1, Polyclonal Antibody

Also Known As

Goat anti-ABCD1 Antibody

Product Synonym Names
ABCD1; ATP-binding cassette, sub-family D (ALD), member 1; ABC42; ALD; ALDP; AMN; adrenoleukodystrophy protein; ABCD1 antibody; ATP-binding cassette; sub-family D (ALD); member 1 antibody; ABC42 antibody; ALD antibody; ALDP antibody; AMN antibody; adrenoleukodystrophy protein antibody; ABCD1
Antibody/Peptide Pairs
ABCD1 peptide (MBS426387) is used for blocking the activity of ABCD1 antibody (MBS420795)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
Immunogen Sequence
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
100ug specific antibody in 200ul (lot specific)
Peptide with sequence C-EDMQRKGYSEQD, from the internal region of the protein sequence according to NP_000024.2.
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ABCD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCD1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-ABCD1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave an approx.50kDa band in Human Brain (Cerebellum) lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 82.9kDa according to NP_000024.2. The 50kDa band was successfully blocked by incubation with the immunizing peptide.

Western Blot (WB) of anti-ABCD1 antibody
HEK293 overexpressing human ABCD1 and probed at 1ug/ml (mock transfection in first lane).
anti-ABCD1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ABCD1. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
82,937 Da
NCBI Official Full Name
ATP-binding cassette sub-family D member 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily D member 1
NCBI Official Symbol
ABCD1  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family D member 1
UniProt Protein Name
ATP-binding cassette sub-family D member 1
UniProt Synonym Protein Names
Adrenoleukodystrophy protein; ALDP
Protein Family
UniProt Gene Name
ABCD1  [Similar Products]
UniProt Synonym Gene Names
ALD; ALDP  [Similar Products]
UniProt Entry Name
NCBI Summary for ABCD1
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCD1
ABCD1: Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. Defects in ABCD1 are the cause of adrenoleukodystrophy X- linked (X-ALD). X-ALD is a peroxisomal metabolic disorder characterized by progressive multifocal demyelination of the central nervous system and by peripheral adrenal insufficiency (Addison disease). It results in mental deterioration, corticospinal tract dysfunction, and cortical blindness. Different clinical manifestations exist like: cerebral childhood ALD (CALD), adult cerebral ALD (ACALD), adrenomyeloneuropathy (AMN) and 'Addison disease only' (ADO) phenotype. The promoter region of ABCD1 is deleted in the chromosome Xq28 deletion syndrome which involves ABCD1 and the neighboring gene BCAP31. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

Protein type: Transporter, ABC family; Transporter; Membrane protein, multi-pass; Hydrolase; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytoplasm; cytosol; integral to peroxisomal membrane; membrane; mitochondrion; perinuclear region of cytoplasm; peroxisomal membrane; peroxisome

Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; enzyme binding; identical protein binding; long-chain fatty acid transporter activity; peroxisomal fatty acyl CoA transporter activity; protein binding; protein homodimerization activity; transporter activity

Biological Process: fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA oxidase; linoleic acid metabolic process; long-chain fatty acid catabolic process; peroxisomal long-chain fatty acid import; peroxisomal membrane transport; peroxisome organization and biogenesis; transmembrane transport; very-long-chain fatty acid catabolic process

Disease: Adrenoleukodystrophy
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