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anti-ABCD2 antibody :: Goat ABCD2 Polyclonal Antibody

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Catalog # MBS422935
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ABCD2, Polyclonal Antibody

Also Known As

Goat anti-ABCD2 (aa460-473) Antibody

Product Synonym Names
ABCD2; ATP-binding cassette, sub-family D (ALD), member 2; ABC39; ALDL1; ALDR; ALDRP; hALDR; ATP-binding cassette sub-family D member 2; adrenoleukodystrophy-like 1; adrenoleukodystrophy-related protein; ABC39 antibody; ABCD2 antibody; adrenoleukodystrophy-like 1 antibody; adrenoleukodystrophy-related protein antibody; ALDL1 antibody; ALDR antibody; ALDRP antibody; ATP-binding cassette sub-family D member 2 antibody; ATP-binding cassette; sub-family D (ALD); member 2 antibody; hALDR antibody; ABCD2 (aa460-473)
Antibody/Peptide Pairs
ABCD2 peptide (MBS427957) is used for blocking the activity of ABCD2 antibody (MBS422935)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
740
Immunogen Sequence
PLSDTLAIKG KVID
OMIM
601081
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-PLSDTLAIKGKVID, from the internal region of the protein sequence according to NP_005155.1.
Epitope
Internal region
Note
No cross-reactivity expected with ABCD1.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ABCD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCD2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-ABCD2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 80kDa band observed in Human Liver lysates (calculated MW of 83.2kDa according to NP_005155.1). Recommended concentration: 0.5-2ug/ml.

Western Blot (WB) of anti-ABCD2 antibody
(1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ABCD2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ABCD2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83,233 Da
NCBI Official Full Name
ATP-binding cassette sub-family D member 2
NCBI Official Synonym Full Names
ATP binding cassette subfamily D member 2
NCBI Official Symbol
ABCD2  [Similar Products]
NCBI Official Synonym Symbols
ALDR; ABC39; ALDL1; ALDRP; hALDR
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family D member 2
UniProt Protein Name
ATP-binding cassette sub-family D member 2
UniProt Synonym Protein Names
Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR
Protein Family
UniProt Gene Name
ABCD2  [Similar Products]
UniProt Synonym Gene Names
ALD1; ALDL1; ALDR; ALDRP; hALDR  [Similar Products]
UniProt Entry Name
ABCD2_HUMAN
NCBI Summary for ABCD2
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCD2
ABCD2: Probable transporter. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

Protein type: Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: cytosol; integral to membrane; intracellular membrane-bound organelle; peroxisomal membrane; peroxisome

Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; long-chain fatty acid transporter activity; protein binding; protein homodimerization activity

Biological Process: fatty acid beta-oxidation; long-chain fatty acid transport; positive regulation of fatty acid beta-oxidation; transmembrane transport; very-long-chain fatty acid catabolic process; very-long-chain fatty acid metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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