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anti-ABCD2 antibody :: Rabbit anti-Human ABCD2 Polyclonal Antibody

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Catalog # MBS9208325
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

ABCD2, Polyclonal Antibody

Also Known As

ABCD2 Antibody (C-term)

Product Synonym Names
ATP-binding cassette sub-family D member 2; Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR; ABCD2; ALD1; ALDL1; ALDR; ALDRP
Antibody/Peptide Pairs
ABCD2 peptide (MBS9219276) is used for blocking the activity of ABCD2 antibody (MBS9208325)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
553-582
Immunogen Sequence Length
740
OMIM
601081
3D Structure
ModBase 3D Structure for Q9UBJ2
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This ABCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human ABCD2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ABCD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCD2 antibody
The protein encoded by this gene is a member of the
superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct
subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
protein is a member of the ALD subfamily, which is involved in
peroxisomal import of fatty acids and/or fatty acyl-CoAs in the
organelle. All known peroxisomal ABC transporters are half
transporters which require a partner half transporter molecule to
form a functional homodimeric or heterodimeric transporter. The
function of this peroxisomal membrane protein is unknown; however
this protein is speculated to function as a dimerization partner of
ABCD1 and/or other peroxisomal ABC transporters. Mutations in this
gene have been observed in patients with adrenoleukodystrophy, a
severe demyelinating disease. This gene has been identified as a
candidate for a modifier gene, accounting for the extreme variation
among adrenoleukodystrophy phenotypes. This gene is also a
candidate for a complement group of Zellweger syndrome, a
genetically heterogeneous disorder of peroxisomal biogenesis.
Applications Tested/Suitable for anti-ABCD2 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-ABCD2 antibody
WB~~1:1000

Western Blot (WB) of anti-ABCD2 antibody
ABCD2 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ABCD2 antibody detected the ABCD2 protein (arrow).
anti-ABCD2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ABCD2 antibody
ABCD2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ABCD2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-ABCD2 antibody Immunohistochemistry (IHC) (IHC) image
Flow Cytometry (FC/FACS) of anti-ABCD2 antibody
ABCD2 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
anti-ABCD2 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
NCBI/Uniprot data below describe general gene information for ABCD2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
83233
NCBI Official Full Name
ATP-binding cassette sub-family D member 2
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family D (ALD), member 2
NCBI Official Symbol
ABCD2  [Similar Products]
NCBI Official Synonym Symbols
ALDR; ABC39; ALDL1; ALDRP; hALDR
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family D member 2
UniProt Protein Name
ATP-binding cassette sub-family D member 2
UniProt Synonym Protein Names
Adrenoleukodystrophy-like 1; Adrenoleukodystrophy-related protein; hALDR
Protein Family
UniProt Gene Name
ABCD2  [Similar Products]
UniProt Synonym Gene Names
ALD1; ALDL1; ALDR; ALDRP; hALDR  [Similar Products]
UniProt Entry Name
ABCD2_HUMAN
NCBI Summary for ABCD2
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCD2
ABCD2: Probable transporter. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: peroxisomal membrane; mitochondrion; intracellular membrane-bound organelle; integral to membrane; peroxisome; cytosol

Molecular Function: protein binding; protein homodimerization activity; ATPase activity, coupled to transmembrane movement of substances; ATP binding

Biological Process: fatty acid beta-oxidation; very-long-chain fatty acid metabolic process; very-long-chain fatty acid catabolic process; transmembrane transport; positive regulation of fatty acid beta-oxidation
Product References and Citations for anti-ABCD2 antibody
Matsukawa, T., et al. Neurogenetics (2010) In press :
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
Maier, E.M., et al. Biochem. Biophys. Res. Commun. 377(1):176-180(2008)
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Petroni, A., et al. J. Inherit. Metab. Dis. 30 (5), 828 (2007) :

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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