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anti-ABHD5 antibody :: Rabbit anti-Human ABHD5 Polyclonal Antibody

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Catalog # MBS9409848
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
Product Name

ABHD5, Polyclonal Antibody

Full Product Name

ABHD5 Antibody

Product Synonym Names
CDS; CGI58; IECN2; NCIE2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
275630
3D Structure
ModBase 3D Structure for Q8WTS1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
The antibody detects endogenous levels of total ABHD5 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
0.5 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to residues near the C terminal of human Abhydrolase domain containing 5
Target Name
ABHD5
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ABHD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABHD5 antibody
The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation.
Product Categories/Family for anti-ABHD5 antibody
Applications Tested/Suitable for anti-ABHD5 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ABHD5 antibody
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:15-1:50

Testing Data of anti-ABHD5 antibody
Gel: 10%SDS-PAGE Lysate: 40ug A431 cell Primary antibody: 1/250 dilution Secondary antibody dilution: 1/8000 Exposure time: 5 seconds
anti-ABHD5 antibody Testing Data image
Immunohistochemistry (IHC) of anti-ABHD5 antibody
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/10.
anti-ABHD5 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ABHD5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,096 Da
NCBI Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
NCBI Official Synonym Full Names
abhydrolase domain containing 5
NCBI Official Symbol
ABHD5  [Similar Products]
NCBI Official Synonym Symbols
CDS; CGI58; IECN2; NCIE2
  [Similar Products]
NCBI Protein Information
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
UniProt Protein Name
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
UniProt Synonym Protein Names
Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58
UniProt Gene Name
ABHD5  [Similar Products]
UniProt Synonym Gene Names
NCIE2  [Similar Products]
UniProt Entry Name
ABHD5_HUMAN
NCBI Summary for ABHD5
The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008]
UniProt Comments for ABHD5
ABHD5: a lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Colocalized with PLIN and ADFP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues, and Chanarin-Dorfman syndrome (CDS), a triglyceride storage disease with impaired long-chain fatty acid oxidation and icthyosis. CDS is an autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons.

Protein type: Lipase; EC 2.3.1.51; Transferase

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: intracellular membrane-bound organelle; cytoplasm; lipid particle; cytosol; nucleus

Molecular Function: triacylglycerol lipase activity; lysophosphatidic acid acyltransferase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity

Biological Process: triacylglycerol catabolic process; phosphatidic acid biosynthetic process; positive regulation of lipoprotein lipase activity; fatty acid metabolic process; cell differentiation

Disease: Chanarin-dorfman Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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