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anti-ABI2 antibody :: Rabbit anti-Human ABI2 Polyclonal Antibody

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Catalog # MBS9608536
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ABI2, Polyclonal Antibody

Popular Item
Also Known As

ABI2 Antibody

Product Synonym Names
Abelson interactor 2; ABI 2; ABI-2; ABI2; ABI2_HUMAN; ABI2B; ABL binding protein 3; ABL interacting protein 1 (SH3 containing protein); ABL interactor 2; ABL interactor protein 2b; ABL-binding protein 3; ABLBP3; AIP 1; Arg binding protein 1; Arg protein tyrosine kinase binding protein; Arg-binding protein 1; ArgBP1; ARGBPIA; ArgBPIB; OTTHUMP00000163783; OTTHUMP00000163784; OTTHUMP00000206182; OTTHUMP00000206183; OTTHUMP00000206184; OTTHUMP00000206185; SSH3BP2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
513
3D Structure
ModBase 3D Structure for Q9NYB9
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
ABI2 antibody detects endogenous levels of total ABI2
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human ABI2
Subcellular Location
Cytoplasm and Cell Projection > Lamellipodium. Cell Projection > Filopodium. Cytoplasm > Cytoskeleton. Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-ABI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABI2 antibody
Function: May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Subunit Structure: Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Interacts with ABL1 and ABL2. Interacts with human cytomegalovirus UL135.
Post-translational Modifications: Is a substrate for ABL1.
Similarity: Belongs to the ABI family.
Applications Tested/Suitable for anti-ABI2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ABI2 antibody
WB: 1:1000-3000

Western Blot (WB) of anti-ABI2 antibody
Western blot analysis of ABI2 using 293 whole cell lysates
anti-ABI2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ABI2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 80 kDa
Predicted: 56 kDa
NCBI Official Full Name
abl interactor 2 isoform a
NCBI Official Synonym Full Names
abl interactor 2
NCBI Official Symbol
NCBI Official Synonym Symbols
AIP1; ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB
  [Similar Products]
NCBI Protein Information
abl interactor 2
UniProt Protein Name
Abl interactor 2
UniProt Synonym Protein Names
Abelson interactor 21 PublicationManual assertion based on opinion iniRef.16"Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)."RIKEN structural genomics initiative (RSGI)Submitted (FEB-2008) to the PDB data bankCited for: STRUCTURE BY NMR OF 444-508.
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
Abi-21 PublicationManual assertion based on opinion iniRef.1; AblBP3; ArgBP11 PublicationManual assertion based on opinion iniRef.3  [Similar Products]
UniProt Comments for ABI2
Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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