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anti-ABL2 antibody :: Rabbit anti-Human ABL Polyclonal Antibody

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Catalog # MBS9210671
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ABL (ABL2), Polyclonal Antibody

Also Known As

ABL Antibody (Y251)

Product Synonym Names
Abelson tyrosine-protein kinase 2; Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG; ABL2; ABLL; ARG
Antibody/Peptide Pairs
ABL (Y251) peptide (MBS9224984) is used for blocking the activity of ABL antibody (MBS9210671)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1064
OMIM
164690
3D Structure
ModBase 3D Structure for P42684
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This ABL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y251 of human ABL.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.26 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ABL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABL2 antibody
ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. The peptide used to generate this antibody is 100% conserved between ABL2 and ABL1.
Product Categories/Family for anti-ABL2 antibody
Applications Tested/Suitable for anti-ABL2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ABL2 antibody
WB~~1:1000

Western Blot (WB) of anti-ABL2 antibody
Western blot analysis of anti-ABL Antibody (Y251) in A2058 cell line lysates (35ug/lane). ABL(arrow) was detected using the purified Pab.
anti-ABL2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ABL2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
128343
NCBI Official Full Name
Abelson tyrosine-protein kinase 2 isoform d
NCBI Official Synonym Full Names
ABL proto-oncogene 2, non-receptor tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
ARG; ABLL
  [Similar Products]
NCBI Protein Information
Abelson tyrosine-protein kinase 2
UniProt Protein Name
Abelson tyrosine-protein kinase 2
UniProt Synonym Protein Names
Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ABLL; ARG  [Similar Products]
UniProt Entry Name
ABL2_HUMAN
NCBI Summary for ABL2
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
UniProt Comments for ABL2
Arg: a cytoplasmic tyrosine kinase of the Abl family. Expressed at the highest levels in mature B cells. Promotes catalase degradation in the oxidative stress response. Localizes to dynamic actin structures and may regulate cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; TK group; Abl family

Chromosomal Location of Human Ortholog: 1q25.2

Cellular Component: extrinsic to internal side of plasma membrane; lamellipodium; dendritic spine; cytosol; phagocytic cup; actin cytoskeleton

Molecular Function: actin filament binding; actin monomer binding; protein binding; protein-tyrosine kinase activity; manganese ion binding; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; ATP binding; protein kinase activity; receptor binding

Biological Process: regulation of cell adhesion; epidermal growth factor receptor signaling pathway; axon guidance; actin filament bundle formation; cell migration; peptidyl-tyrosine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein binding; dendrite morphogenesis; alpha-beta T cell differentiation; protein modification process; cerebellum morphogenesis; platelet-derived growth factor receptor signaling pathway; signal transduction; substrate-bound cell migration, cell extension; phagocytosis; regulation of cell proliferation; regulation of apoptosis; Bergmann glial cell differentiation; elevation of cytosolic calcium ion concentration; negative regulation of Rho protein signal transduction; regulation of endocytosis; innate immune response; visual learning; regulation of autophagy; negative regulation of cell-cell adhesion; neuromuscular process controlling balance; neuron remodeling; positive regulation of oxidoreductase activity
Product References and Citations for anti-ABL2 antibody
Cao, C., et al., Biochemistry 42(35):10348-10353 (2003).
Cao, C., et al., J. Biol. Chem. 278(32):29667-29675 (2003).
Kruh, G.D., et al., Proc. Natl. Acad. Sci. U.S.A. 87(15):5802-5806 (1990).
Kruh, G.D., et al., Science 234(4783):1545-1548 (1986).
Bianchi, C., et al., FEBS Lett. 527 (1-3), 216-222 (2002).

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Disclaimer
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