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anti-AOC1 antibody :: Rabbit anti-Human ABP1 Polyclonal Antibody

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Catalog # MBS9201293
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ABP1 (AOC1), Polyclonal Antibody

Also Known As

ABP1 Antibody (N-term)

Product Synonym Names
Amiloride-sensitive amine oxidase [copper-containing]; DAO; Diamine oxidase; Amiloride-binding protein 1; Amine oxidase copper domain-containing protein 1; Histaminase; Kidney amine oxidase; KAO; AOC1; ABP1; DAO1
Antibody/Peptide Pairs
ABP1 peptide (MBS9220313) is used for blocking the activity of ABP1 antibody (MBS9201293)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
71-100
Immunogen Sequence Length
770
OMIM
104610
3D Structure
ModBase 3D Structure for P19801
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This ABP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human ABP1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-AOC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AOC1 antibody
This gene encodes a membrane glycoprotein that is
expressed in many epithelium-rich and/or hematopoietic tissues and
oxidatively deaminates putrescine and histamine. The protein may
play a role in controlling the level of histamine and/or putrescine
in these tissues. It also binds to and is inhibited by amiloride, a
diuretic that acts by closing epithelial sodium ion channels.
Product Categories/Family for anti-AOC1 antibody
Applications Tested/Suitable for anti-AOC1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-AOC1 antibody
WB~~1:1000

Western Blot (WB) of anti-AOC1 antibody
ABP1 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ABP1 antibody detected the ABP1 protein (arrow).
anti-AOC1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for AOC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
85378
NCBI Official Full Name
amiloride-sensitive amine oxidase
NCBI Official Synonym Full Names
amine oxidase, copper containing 1
NCBI Official Symbol
NCBI Official Synonym Symbols
ABP; DAO; KAO; ABP1; DAO1
  [Similar Products]
NCBI Protein Information
amiloride-sensitive amine oxidase [copper-containing]
UniProt Protein Name
Amiloride-sensitive amine oxidase [copper-containing]
UniProt Synonym Protein Names
Amiloride-binding protein 1; Amine oxidase copper domain-containing protein 1; Histaminase; Kidney amine oxidase; KAO
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ABP1; DAO1; DAO; Diamine oxidase; KAO  [Similar Products]
UniProt Entry Name
AOC1_HUMAN
NCBI Summary for AOC1
This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
UniProt Comments for AOC1
ABP1: Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. Belongs to the copper/topaquinone oxidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.4.3.22; Amino Acid Metabolism - histidine; Secreted; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - arginine and proline; Oxidoreductase; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: extracellular space; tight junction; plasma membrane; peroxisome

Molecular Function: heparin binding; amine oxidase activity; copper ion binding; protein homodimerization activity; zinc ion binding; protein complex binding; drug binding; cation channel activity; receptor activity; calcium ion binding; sodium channel activity; quinone binding

Biological Process: response to drug; response to antibiotic; amine metabolic process
Product References and Citations for anti-AOC1 antibody
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
McGrath, A.P., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 2), 137-142 (2010) :
Chambers, J.C., et al. Nat. Genet. 42(2):149-152(2010)
McGrath, A.P., et al. Biochemistry 48(41):9810-9822(2009)
Song, W.B., et al. World J. Gastroenterol. 15(31):3916-3919(2009)

Precautions
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Disclaimer
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