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anti-ABRA antibody :: Rabbit anti-Human ABRA Polyclonal Antibody

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Catalog # MBS9208483
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

ABRA, Polyclonal Antibody

Also Known As

ABRA Antibody (C-term)

Product Synonym Names
Actin-binding Rho-activating protein; Striated muscle activator of Rho-dependent signaling; STARS; ABRA {ECO:0000312|EMBL:AAI051061}
Antibody/Peptide Pairs
ABRA peptide (MBS9219436) is used for blocking the activity of ABRA antibody (MBS9208483)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
275-304
Immunogen Sequence Length
381
OMIM
609747
3D Structure
ModBase 3D Structure for Q8N0Z2
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Specificity
This ABRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-304 amino acids from the C-terminal region of human ABRA.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ABRA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABRA antibody
ABRA acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity).
Applications Tested/Suitable for anti-ABRA antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ABRA antibody
WB~~1:1000

Western Blot (WB) of anti-ABRA antibody
ABRA Antibody (C-term) western blot analysis in human normal Uterus tissue lysates (35ug/lane).This demonstrates the ABRA antibody detected the ABRA protein (arrow).
anti-ABRA antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ABRA antibody
ABRA Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ABRA Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-ABRA antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ABRA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
43117
NCBI Official Full Name
actin-binding Rho-activating protein
NCBI Official Synonym Full Names
actin binding Rho activating protein
NCBI Official Symbol
NCBI Official Synonym Symbols
STARS
  [Similar Products]
NCBI Protein Information
actin-binding Rho-activating protein
UniProt Protein Name
Actin-binding Rho-activating protein
UniProt Synonym Protein Names
Striated muscle activator of Rho-dependent signaling; STARS
UniProt Gene Name
UniProt Synonym Gene Names
STARS  [Similar Products]
UniProt Entry Name
ABRA_HUMAN
UniProt Comments for ABRA
ABRA: Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.

Protein type: Transcription, coactivator/corepressor; Contractile; Actin-binding

Chromosomal Location of Human Ortholog: 8q23.1

Cellular Component: sarcomere; plasma membrane; actin cytoskeleton

Molecular Function: transcription coactivator activity; actin binding

Biological Process: transcription, DNA-dependent; protein import into nucleus, translocation; positive regulation of Rho protein signal transduction; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter
Product References and Citations for anti-ABRA antibody
Lamon, S., et al. J. Physiol. (Lond.) 587 (PT 8), 1795-1803 (2009) : Kuwahara, K., et al. J. Clin. Invest. 117(5):1324-1334(2007) Kuwahara, K., et al. Mol. Cell. Biol. 25(8):3173-3181(2005) Arai, A., et al. J. Biol. Chem. 277(27):24453-24459(2002) Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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