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anti-ACACB antibody :: Goat ACACB Polyclonal Antibody

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Catalog # MBS423248
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-ACACB antibody
Product Name

ACACB, Polyclonal Antibody

Also Known As

Goat anti-ACACB (aa146-159) Antibody

Product Synonym Names
Goat Anti-ACACB Antibody; ACACB; acetyl-CoA carboxylase beta; ACC2; ACCB; HACC275; ACC-beta; acetyl-CoA carboxylase 2; acetyl-Coenzyme A carboxylase beta; ACC2 antibody; ACCB antibody; ACC-beta antibody; acetyl-CoA carboxylase 2 antibody; acetyl-CoA carboxylase beta antibody; acetyl-Coenzyme A carboxylase beta antibody; HACC275 antibody; ACACB antibody; ACACB (aa146-159)
Antibody/Peptide Pairs
ACACB peptide (MBS428121) is used for blocking the activity of ACACB antibody (MBS423248)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
Immunogen Sequence
Species Reactivity
Expected from sequence similarity: Human
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
100ug specific antibody in 200ul (lot specific)
Peptide with sequence C-SPSKEDKKQANIKR, from the internal reion (near N Terminus) of the protein sequence according to NP_001084.3.
Internal region (near N Terminus)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ACACB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ACACB antibody
Peptide ELISA (EIA)
Application Notes for anti-ACACB antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as large as the calculated size of 277kDa according to NP_001084.3. Therefore we cannot recommend an optimal concentration and the antibody is an aspiring product.
NCBI/Uniprot data below describe general gene information for ACACB. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
255,093 Da
NCBI Official Full Name
acetyl-CoA carboxylase 2
NCBI Official Synonym Full Names
acetyl-CoA carboxylase beta
NCBI Official Symbol
ACACB  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
acetyl-CoA carboxylase 2
UniProt Protein Name
Acetyl-CoA carboxylase 2
UniProt Synonym Protein Names
ACC-betaIncluding the following 1 domains:Biotin carboxylase (EC:
UniProt Gene Name
ACACB  [Similar Products]
UniProt Synonym Gene Names
ACC2; ACCB  [Similar Products]
UniProt Entry Name
NCBI Summary for ACACB
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for ACACB
ACC2: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Activity is increased by oligomerization. Activated by citrate. Citrate and MID1IP1 promote oligomerization. Inhibited by malonyl-CoA. ACC1 is the predominant form expressed in liver, adipocyte and mammary gland. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC2 is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Two isoforms of the human protein are produced by alternative splicing.

Protein type: EC; Ligase; EC; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - propanoate; Lipid Metabolism - fatty acid biosynthesis; Mitochondrial

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: cytosol; endomembrane system; mitochondrial outer membrane; mitochondrion; nucleus

Molecular Function: acetyl-CoA carboxylase activity; ATP binding; biotin carboxylase activity; metal ion binding; protein binding

Biological Process: acetyl-CoA metabolic process; biotin metabolic process; carnitine shuttle; fatty acid biosynthetic process; negative regulation of catalytic activity; negative regulation of fatty acid beta-oxidation; positive regulation of cellular metabolic process; protein homotetramerization; response to nutrient levels
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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