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anti-ACIN1 antibody :: Rabbit anti-Human ACIN1 / Acinus Polyclonal Antibody

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Catalog # MBS247455
Unit / Price
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  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

ACIN1 / Acinus, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human ACIN1 / Acinus

Product Synonym Names
Anti-ACIN1 / Acinus Antibody IHC-plus; ACIN1; ACINUS; ACN; KIAA0670; FSAP152; Acinus; Human ACIN1; Acinus
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
604562
3D Structure
ModBase 3D Structure for Q9UKV3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Specificity
Peptide corresponding to amino acids near the carboxy terminus of human AcinusL, which are identical to those of mouse Acinus.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.02% sodium azide.
Target Species
Human
Immunogen Description
Synthetic peptide from human ACIN1 / Acinus.
Immunogen Type
Synthetic peptide
Immunogen
ACIN1 / Acinus antibody was raised against synthetic peptide from human ACIN1 / Acinus.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Other Notes
Small volumes of anti-ACIN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ACIN1 antibody
Applications Tested/Suitable for anti-ACIN1 antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB), ELISA (EIA)
Application Notes for anti-ACIN1 antibody
ELISA, ICC, IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-ACIN1 antibody
Anti-ACIN1 / Acinus antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ACIN1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ACIN1 antibody
Anti-ACIN1 / Acinus antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ACIN1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ACIN1 antibody
Anti-ACIN1 / Acinus antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ACIN1 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-ACIN1 antibody
Immunofluorescence of Acinus in K562 cells with Acinus antibody at 20 ug/ml.
anti-ACIN1 antibody Immunofluorescence (IF) image
Immunocytochemistry (ICC) of anti-ACIN1 antibody
Immunocytochemistry of Acinus in K562 cells with Acinus antibody at 0.5 µg/ml.
anti-ACIN1 antibody Immunocytochemistry (ICC) (ICC) image
Western Blot (WB) of anti-ACIN1 antibody
Western blot of Acinus in K562 whole cell lysate with Acinus antibody at 0.5 ug/ml.
anti-ACIN1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ACIN1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
150,557 Da
NCBI Official Full Name
apoptotic chromatin condensation inducer in the nucleus isoform 1
NCBI Official Synonym Full Names
apoptotic chromatin condensation inducer 1
NCBI Official Symbol
ACIN1  [Similar Products]
NCBI Official Synonym Symbols
ACN; ACINUS; fSAP152
  [Similar Products]
NCBI Protein Information
apoptotic chromatin condensation inducer in the nucleus; functional spliceosome-associated protein 152
UniProt Protein Name
Apoptotic chromatin condensation inducer in the nucleus
UniProt Gene Name
ACIN1  [Similar Products]
UniProt Synonym Gene Names
ACINUS; KIAA0670; Acinus  [Similar Products]
UniProt Entry Name
ACINU_HUMAN
NCBI Summary for ACIN1
Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA fragmentation. This protein has also been shown to be a component of a splicing-dependent multiprotein exon junction complex (EJC) that is deposited at splice junctions on mRNAs, as a consequence of pre-mRNA splicing. It may thus be involved in mRNA metabolism associated with splicing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
UniProt Comments for ACIN1
acinus: an ubiquitous RNA-binding protein. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC is composed of ACIN1, CASC3, DDX48, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5. Phosphorylation by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm, and up-regulates its stimulatory effect on cyclin A1. Activated by proteolytic cleavage. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Four alternatively spliced human isoforms have been described.

Protein type: Apoptosis; RNA splicing; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleolus; nuclear speck; nucleus; cytosol

Molecular Function: protein binding; enzyme binding; nucleic acid binding; ATPase activity; nucleotide binding

Biological Process: positive regulation of monocyte differentiation; negative regulation of nuclear mRNA splicing, via spliceosome; apoptosis; positive regulation of apoptosis; RNA splicing; erythrocyte differentiation; mRNA processing; apoptotic chromosome condensation; cell structure disassembly during apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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