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anti-ACSL4 antibody :: Rabbit anti-Human ACSL4 Polyclonal Antibody

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Catalog # MBS7004469
Unit / Price
  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

ACSL4, Polyclonal Antibody

Popular Item
Also Known As

ACSL4 Antibody

Product Synonym Names
Long-chain-fatty-acid--CoA ligase 4; Long-chain acyl-CoA synthetase 4; LACS 4; ACSL4; ACS4; FACL4; LACS4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
670
OMIM
300157
3D Structure
ModBase 3D Structure for O60488
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Liquid
Immunogen
Recombinant human Long-chain-fatty-acid--CoA ligase 4 protein
Conjugation
Non-conjugated
Storage Buffer
Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47995 / sc-47997 / sc-47996
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ACSL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACSL4 antibody
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
Applications Tested/Suitable for anti-ACSL4 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ACSL4 antibody
Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

Western Blot (WB) of anti-ACSL4 antibody
Western blot
All lanes: ACSL4 antibody at 2ug/ml
Lane 1:HepG2 whole cell lysate
Lane 2:Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 80,75 kDa
Observed band size: 79 kDa

anti-ACSL4 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ACSL4 antibody
Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7004469 at dilution 1:100
anti-ACSL4 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ACSL4 antibody
Immunohistochemistry of paraffin-embedded human breast cancer tissue using MBS7004469 at dilution 1:100
anti-ACSL4 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ACSL4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
74,436 Da
NCBI Official Full Name
long-chain-fatty-acid--CoA ligase 4 isoform 1
NCBI Official Synonym Full Names
acyl-CoA synthetase long-chain family member 4
NCBI Official Symbol
ACSL4  [Similar Products]
NCBI Official Synonym Symbols
ACS4; FACL4; LACS4; MRX63; MRX68
  [Similar Products]
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 4
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 4
UniProt Synonym Protein Names
Long-chain acyl-CoA synthetase 4; LACS 4
UniProt Gene Name
ACSL4  [Similar Products]
UniProt Synonym Gene Names
ACS4; FACL4; LACS4; LACS 4  [Similar Products]
UniProt Entry Name
ACSL4_HUMAN
NCBI Summary for ACSL4
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for ACSL4
ACSL4: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Defects in ACSL4 are the cause of mental retardation X- linked type 63 (MRX63). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Ligase; EC 6.2.1.3; Lipid Metabolism - fatty acid

Chromosomal Location of Human Ortholog: Xq22.3-q23

Cellular Component: cell soma; cytoplasm; endoplasmic reticulum membrane; integral to membrane; lipid particle; membrane; mitochondrial outer membrane; peroxisomal membrane

Molecular Function: arachidonate-CoA ligase activity; ATP binding; long-chain-fatty-acid-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity

Biological Process: cellular lipid metabolic process; embryonic process involved in female pregnancy; fatty acid transport; lipid biosynthetic process; lipid metabolic process; long-chain fatty acid metabolic process; negative regulation of prostaglandin secretion; positive regulation of cell growth; response to nutrient; triacylglycerol biosynthetic process

Disease: Mental Retardation, X-linked 63
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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