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anti-ADAMTS1 antibody :: Goat anti-Human ADAMTS1 Propeptide 1 Polyclonal Antibody

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Catalog # MBS621940
Unit / Price
  0.1 mg  /  $725 +1 FREE 8GB USB
anti-ADAMTS1 antibody
Product Name

ADAMTS1 Propeptide 1, Polyclonal Antibody

Also Known As

ADAMTS1 Propeptide 1 (A Disintegrin And Metalloproteinase with ThromboSpondin-1 motif, METH-1)

Product Synonym Names
Anti -ADAMTS1 Propeptide 1 (A Disintegrin And Metalloproteinase with ThromboSpondin-1 motif, METH-1)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 21; NC_000021.8 (28208606..28217728, complement). Location: 21q21.2
3D Structure
ModBase 3D Structure for Q5HYL0
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Specificity
Recognizes human ADAMTS1 Propeptide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS with 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
Immunogen
NS0-derived, recombinat human ADAMTS1 Propeptide; aa50-252.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-ADAMTS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ADAMTS1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-ADAMTS1 antibody
Suitable for use in ELISA, Western Blot, and Immunoprecipitation.
Dilution: ELISA: 0.5-1.0ug/ml
Western Blot: 0.1-0.2ug/ml
Immunoprecipitation: 15ug/ml
NCBI/Uniprot data below describe general gene information for ADAMTS1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
105,354 Da[Similar Products]
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 1
NCBI Official Symbol
ADAMTS1  [Similar Products]
NCBI Official Synonym Symbols
C3-C5; METH1; KIAA1346
  [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; OTTHUMP00000096354; human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
UniProt Protein Name
Putative uncharacterized protein DKFZp686E01144
UniProt Gene Name
DKFZp686E01144  [Similar Products]
UniProt Entry Name
Q5HYL0_HUMAN
NCBI Summary for ADAMTS1
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq]
UniProt Comments for ADAMTS1
ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Protein type: Secreted; Protease; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 21q21.2

Cellular Component: cytoplasm; basement membrane; cytoplasmic vesicle

Molecular Function: heparin binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: integrin-mediated signaling pathway; negative regulation of cell proliferation; ovulation from ovarian follicle; kidney development; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-ADAMTS1 antibody
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