NP_001020376.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,389 Da
NCBI Official Full Name
AP-2 complex subunit mu isoform b
NCBI Official Synonym Full Names
adaptor related protein complex 2 mu 1 subunit
NCBI Protein Information
AP-2 complex subunit mu
UniProt Protein Name
AP-2 complex subunit mu
UniProt Synonym Protein Names
AP-2 mu chain; Adaptin-mu2; Adaptor protein complex AP-2 subunit mu; Adaptor-related protein complex 2 subunit mu; Clathrin assembly protein complex 2 mu medium chain; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; HA2 50 kDa subunit; Plasma membrane adaptor AP-2 50 kDa protein
UniProt Synonym Gene Names
NCBI Summary for AP2m1
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
UniProt Comments for AP2m1
AP2M1: a protein of the adaptor complexes medium subunit family. A subunit of the heterotetrameric coat assembly protein complex 2 (AP2) which links clathrin to receptors in coated vesicles. Interacts with the cytoplasmic tails of membrane proteins and polyphosphoinositide-containing lipids. Is not required for clathrin-coated vesicle formation at the plasma membrane, but that it is one of several endocytic adaptors required for the uptake of certain cargo proteins. Is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP-2 is a heterotetramer composed of two large chains (alpha and beta), a medium chain (AP50) and a small chain (AP17).
Protein type: Adaptor/scaffold; Vesicle
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: AP-2 adaptor complex; clathrin-coated endocytic vesicle; cytosol; extracellular exosome; lysosomal membrane; plasma membrane
Molecular Function: ion channel binding; lipid binding; low-density lipoprotein receptor binding; protein binding; signal sequence binding; transporter activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; clathrin-dependent endocytosis; ephrin receptor signaling pathway; intracellular protein transport; low-density lipoprotein particle clearance; low-density lipoprotein particle receptor catabolic process; microtubule-based movement; receptor internalization; regulation of defense response to virus by virus; vesicle organization and biogenesis; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on AP2m1
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Pathways associated with anti-AP2m1 antibody
Diseases associated with anti-AP2m1 antibody
Organs/Tissues associated with anti-AP2m1 antibody
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