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anti-ADRA2B antibody :: Rabbit anti-Human ADRA2B Polyclonal Antibody

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Catalog # MBS628940
Unit / Price
  0.2 mL  /  $610 +1 FREE 8GB USB
anti-ADRA2B antibody
Product Name

ADRA2B, Polyclonal Antibody

Full Product Name

ADRA2B, ID (Alpha-2B Adrenergic Receptor, Alpha-2B Adrenoreceptor, Alpha-2B Adrenoceptor, Alpha-2BAR, Alpha-2 Adrenergic Receptor Subtype C2, ADRA2L1, ADRA2RL1)

Product Synonym Names
Anti -ADRA2B, ID (Alpha-2B Adrenergic Receptor, Alpha-2B Adrenoreceptor, Alpha-2B Adrenoceptor, Alpha-2BAR, Alpha-2 Adrenergic Receptor Subtype C2, ADRA2L1, ADRA2RL1)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (96778623..96781888, complement). Location: 2p13-q13
OMIM
104260
3D Structure
ModBase 3D Structure for P18089
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Specificity
Recognizes human ADRA2B.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide selected from the Center region of human ADRA2B (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ADRA2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADRA2B antibody
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
Product Categories/Family for anti-ADRA2B antibody
Applications Tested/Suitable for anti-ADRA2B antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ADRA2B antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
NCBI/Uniprot data below describe general gene information for ADRA2B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,954 Da[Similar Products]
NCBI Official Full Name
alpha-2B adrenergic receptor
NCBI Official Synonym Full Names
adrenergic, alpha-2B-, receptor
NCBI Official Symbol
ADRA2B  [Similar Products]
NCBI Official Synonym Symbols
ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR
  [Similar Products]
NCBI Protein Information
alpha-2B adrenergic receptor; alpha-2BAR; OTTHUMP00000205577; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; G-protein coupled receptor; adrenergic receptor alpha 2B; alpha-2B-adrenergic receptor; alpha-2-adrenergic receptor-like 1; ADRA2B adrenergic, alpha-2B-, receptor; alpha-2 adrenergic receptor subtype C2
UniProt Protein Name
Alpha-2B adrenergic receptor
UniProt Synonym Protein Names
Alpha-2 adrenergic receptor subtype C2; Alpha-2B adrenoreceptor
UniProt Gene Name
ADRA2B  [Similar Products]
UniProt Synonym Gene Names
ADRA2L1; ADRA2RL1  [Similar Products]
UniProt Entry Name
ADA2B_HUMAN
NCBI Summary for ADRA2B
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. [provided by RefSeq]
UniProt Comments for ADRA2B
ADRA2B: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q11.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; alpha2-adrenergic receptor activity; epinephrine binding

Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; cell-cell signaling; activation of protein kinase B; regulation of vascular smooth muscle contraction; MAPKKK cascade; negative regulation of epinephrine secretion; angiogenesis; female pregnancy; positive regulation of neuron differentiation; blood coagulation; positive regulation of blood pressure

Disease: Epilepsy, Familial Adult Myoclonic, 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-ADRA2B antibody
 Reference Product  PubMed Publications
 GNAI2 antibody  >2 publications with ADRA2B and GNAI2
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